Alexander Dmitriev
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Explore the profile of Alexander Dmitriev including associated specialties, affiliations and a list of published articles.
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23
Citations
132
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Recent Articles
11.
Rudik A, Dmitriev A, Lagunin A, Filimonov D, Poroikov V
Mol Inform
. 2020 Nov;
40(4):e2000231.
PMID: 33191610
Most drug-like compounds can interact with several pharmacological targets and exhibit complex biological activity spectra. Analysis of these spectra helps find and optimize new pharmaceutical agents or identify new uses...
12.
Perepelina K, Kostina A, Klauzen P, Khudiakov A, Rabino M, Crasto S, et al.
Stem Cell Res
. 2020 Jul;
47:101895.
PMID: 32659731
Human iPSC lines were generated from peripheral blood mononuclear cells of patient carrying LMNA mutation associated with Emery-Dreifuss muscular dystrophy accompanied by atrioventricular block and paroxysmal atrial fibrillation. Reprogramming factors...
13.
Dmitriev A, Filimonov D, Lagunin A, Karasev D, Pogodin P, Rudik A, et al.
Molecules
. 2019 Nov;
24(21).
PMID: 31683720
Drug-drug interactions (DDIs) severity assessment is a crucial problem because polypharmacy is increasingly common in modern medical practice. Many DDIs are caused by alterations of the plasma concentrations of one...
14.
Rudik A, Bezhentsev V, Dmitriev A, Lagunin A, Filimonov D, Poroikov V
J Bioinform Comput Biol
. 2019 Mar;
17(1):1940001.
PMID: 30866738
Xenobiotics biotransformation in humans is a process of the chemical modifications, which may lead to the formation of toxic metabolites. The prediction of such metabolites is very important for drug...
15.
Tarasova O, Rudik A, Dmitriev A, Lagunin A, Filimonov D, Poroikov V
Molecules
. 2017 Dec;
22(12).
PMID: 29194399
Metabolism of xenobiotics (Greek : exogenous substances) plays an essential role in the prediction of biological activity and testing for the subsequent research and development of new drug candidates. Integration...
16.
Vasilyeva A, Santos Sanches I, Florindo C, Dmitriev A
PLoS One
. 2015 Jun;
10(6):e0128426.
PMID: 26047354
Streptococcus agalactiae genome encodes 21 two-component systems (TCS) and a variety of regulatory proteins in order to control gene expression. One of the TCS, BgrRS, comprising the BgrR DNA-binding regulatory...
17.
Rudik A, Dmitriev A, Lagunin A, Filimonov D, Poroikov V
Bioinformatics
. 2015 Mar;
31(12):2046-8.
PMID: 25777527
Unlabelled: A new freely available web server site of metabolism predictor to predict the sites of metabolism (SOM) based on the structural formula of chemicals has been developed. It is...
18.
Anbalagan S, Dmitriev A, McShan W, Dunman P, Chaussee M
J Bacteriol
. 2012 May;
194(15):3961-71.
PMID: 22636768
Streptococcus pyogenes Rgg is a transcriptional regulator that interacts with the cofactor LacD.1 to control growth phase-dependent expression of genes, including speB, which encodes a secreted cysteine protease. LacD.1 is...
19.
Dmitriev A, Mohapatra S, Chong P, Neely M, Biswas S, Biswas I
PLoS One
. 2011 Jun;
6(5):e20127.
PMID: 21655290
CovR/S is a two-component signal transduction system (TCS) that controls the expression of various virulence related genes in many streptococci. However, in the dental pathogen Streptococcus mutans, the response regulator...
20.
Hu H, He L, Dmitriev A, Hu Y, Deng J, Zhang W, et al.
Pediatr Infect Dis J
. 2008 Aug;
27(10):942-4.
PMID: 18756187
To analyze the role of Haemophilus influenzae type b in children's death resulting from severe pneumonia conventional PCR, Southern blotting and in situ PCR were evaluated for the detection of...