Alexander D McLellan
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Explore the profile of Alexander D McLellan including associated specialties, affiliations and a list of published articles.
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49
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1365
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Recent Articles
1.
Lam P, Omer N, Wong J, Tu C, Alim L, Rossi G, et al.
Clin Transl Med
. 2025 Jan;
15(1):e70140.
PMID: 39763064
Background: Paediatric sarcomas, including rhabdomyosarcoma, Ewing sarcoma and osteosarcoma, represent a group of malignancies that significantly contribute to cancer-related morbidity and mortality in children and young adults. These cancers share...
2.
Rad S, Wannigama D, Hirankarn N, McLellan A
Sci Rep
. 2023 Oct;
13(1):16945.
PMID: 37805621
Non-synonymous mutations in the SARS-CoV-2 spike region affect cell entry, tropism, and immune evasion, while frequent synonymous mutations may modify viral fitness. Host microRNAs, a type of non-coding RNA, play...
3.
Dobson L, Saunderson S, Smith-Bell S, McLellan A
Immunol Cell Biol
. 2023 Aug;
101(9):847-856.
PMID: 37585342
Artificial antigen-presenting cells (aAPCs) offer a cost effective and convenient tool for the expansion of chimeric antigen receptor (CAR)-bearing T cells and NK cells. aAPCs are particularly useful because of...
4.
Wannigama D, Amarasiri M, Hongsing P, Hurst C, Modchang C, Chadsuthi S, et al.
iScience
. 2023 Jun;
26(7):107019.
PMID: 37351501
Equitable SARS-CoV-2 surveillance in low-resource communities lacking centralized sewers is critical as wastewater-based epidemiology (WBE) progresses. However, large-scale studies on SARS-CoV-2 detection in wastewater from low-and middle-income countries is limited...
5.
Wannigama D, Amarasiri M, Hongsing P, Hurst C, Modchang C, Chadsuthi S, et al.
Sci Total Environ
. 2022 Dec;
858(Pt 1):159816.
PMID: 36461562
The monkeypox virus is excreted in the feces of infected individuals. Therefore, there is an interest in using viral load detection in wastewater for sentinel early surveillance at a community...
6.
Saunderson S, Hosseini-Rad S, McLellan A
Genes (Basel)
. 2022 Oct;
13(10).
PMID: 36292564
Tetracycline-inducible systems are widely used control elements for mammalian gene expression. Despite multiple iterations to improve inducibility, their use is still compromised by basal promoter activity in the absence of...
7.
Ali Hosseini Rad S, Halpin J, Tawinwung S, Suppipat K, Hirankarn N, McLellan A
Immunol Cell Biol
. 2022 May;
100(6):424-439.
PMID: 35507473
Advances made in chimeric antigen receptor (CAR) T cell therapy have revolutionized the treatment and management of certain cancers. Currently, B cell malignancies have been among the few cancers to...
8.
White L, Goy H, Rose A, McLellan A
Cancers (Basel)
. 2022 Feb;
14(4).
PMID: 35205725
The precision guiding of endogenous or adoptively transferred lymphocytes to the solid tumour mass is obligatory for optimal anti-tumour effects and will improve patient safety. The recognition and elimination of...
9.
Rad S M A, Halpin J, Mollaei M, Smith Bell S, Hirankarn N, McLellan A
Cancers (Basel)
. 2021 Apr;
13(6).
PMID: 33799768
Chimeric antigen receptor (CAR) T-cell therapy has revolutionized adoptive cell therapy with impressive therapeutic outcomes of >80% complete remission (CR) rates in some haematological malignancies. Despite this, CAR T cell...
10.
Rad S, Tan G, Poudel A, He K, McLellan A
Gene
. 2020 Aug;
762:145016.
PMID: 32777522
Mcl-1 is a member of the Bcl-2 anti-apoptotic protein family with important roles in the development, lifespan and metabolism of lymphocytes, as well as oncogenesis. Mcl-1 displays the shortest half-life...