Alexander D Kloth
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Explore the profile of Alexander D Kloth including associated specialties, affiliations and a list of published articles.
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11
Citations
780
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Recent Articles
1.
Kiffmeyer E, Cosgrove J, Siganos J, Bien H, Vipond J, Vogt K, et al.
NeuroSci
. 2023 Jun;
3(4):624-644.
PMID: 37366488
Recently, there has been increased interest in the role of the cerebellum in autism spectrum disorders (ASD). To better understand the pathophysiological role of the cerebellum in ASD, it is...
2.
Cosgrove J, Kelly L, Kiffmeyer E, Kloth A
Brain Behav
. 2022 Jan;
12(2):e2468.
PMID: 34985196
Introduction: Angelman syndrome (AS) is a rare neurodevelopmental disorder caused by mutation or loss of UBE3A and marked by intellectual disability, ataxia, autism-like symptoms, and other atypical behaviors. One route...
3.
Poppens M, Cain J, Johnson T, White K, Davis S, Laufmann R, et al.
Orphanet J Rare Dis
. 2019 Jan;
14(1):19.
PMID: 30665444
Background: CLN6-Batten disease is a rare neurodevelopmental disorder characterized pathologically by the accumulation of lysosomal storage material, glial activation and neurodegeneration, and phenotypically by loss of vision, motor coordination, and...
4.
Brockett A, Kane G, Monari P, Briones B, Vigneron P, Barber G, et al.
PLoS One
. 2018 Apr;
13(4):e0195726.
PMID: 29664924
The medial prefrontal cortex (mPFC) is important for cognitive flexibility, the ability to switch between two task-relevant dimensions. Changes in neuronal oscillations and alterations in the coupling across frequency ranges...
5.
Thaxton C, Kloth A, Clark E, Moy S, Chitwood R, Philpot B
J Neurosci
. 2017 Dec;
38(4):918-936.
PMID: 29222403
Mutations or deletions of the transcription factor are linked to Pitt-Hopkins syndrome (PTHS) and schizophrenia, suggesting that the precise pathogenic mutations dictate cellular, synaptic, and behavioral consequences. Here, we generated...
6.
Giovannucci A, Badura A, Deverett B, Najafi F, Pereira T, Gao Z, et al.
Nat Neurosci
. 2017 Mar;
20(5):727-734.
PMID: 28319608
Cerebellar granule cells, which constitute half the brain's neurons, supply Purkinje cells with contextual information necessary for motor learning, but how they encode this information is unknown. Here we show,...
7.
Kloth A, Badura A, Li A, Cherskov A, Connolly S, Giovannucci A, et al.
Elife
. 2015 Jul;
4:e06085.
PMID: 26158416
Sensory integration difficulties have been reported in autism, but their underlying brain-circuit mechanisms are underexplored. Using five autism-related mouse models, Shank3+/ΔC, Mecp2(R308/Y), Cntnap2-/-, L7-Tsc1 (L7/Pcp2(Cre)::Tsc1(flox/+)), and patDp(15q11-13)/+, we report specific...
8.
Piochon C, Kloth A, Grasselli G, Titley H, Nakayama H, Hashimoto K, et al.
Nat Commun
. 2015 Jan;
6:6014.
PMID: 25625889
No abstract available.
9.
Piochon C, Kloth A, Grasselli G, Titley H, Nakayama H, Hashimoto K, et al.
Nat Commun
. 2014 Nov;
5:5586.
PMID: 25418414
A common feature of autism spectrum disorder (ASD) is the impairment of motor control and learning, occurring in a majority of children with autism, consistent with perturbation in cerebellar function....
10.
Schoenfeld T, Kloth A, Hsueh B, Runkle M, Kane G, Wang S, et al.
J Neurosci
. 2014 Nov;
34(47):15679-88.
PMID: 25411496
Anxiety disorders are highly prevalent but little is known about their underlying mechanisms. Gap junctions exist in brain regions important for anxiety regulation, such as the ventral hippocampus (vHIP) and...