Alexander D Fellows
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Explore the profile of Alexander D Fellows including associated specialties, affiliations and a list of published articles.
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9
Citations
287
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Recent Articles
1.
Fellows A, Bruntraeger M, Burgold T, Bassett A, Carter A
J Cell Biol
. 2024 Feb;
223(5).
PMID: 38407313
Axonal transport is essential for neuronal survival. This is driven by microtubule motors including dynein, which transports cargo from the axon tip back to the cell body. This function requires...
2.
Rhymes E, Tosolini A, Fellows A, Mahy W, McDonald N, Schiavo G
Cell Death Dis
. 2022 Jul;
13(7):584.
PMID: 35798698
Deficits in axonal transport are one of the earliest pathological outcomes in several models of amyotrophic lateral sclerosis (ALS), including SOD1 mice. Evidence suggests that rescuing these deficits prevents disease...
3.
Leese C, Bresnahan R, Doran C, Simsek D, Fellows A, Restani L, et al.
Toxicon X
. 2020 Mar;
5:100019.
PMID: 32140681
Neurological diseases constitute a quarter of global disease burden and are expected to rise worldwide with the ageing of human populations. There is an increasing need to develop new molecular...
4.
Fellows A, Rhymes E, Gibbs K, Greensmith L, Schiavo G
EMBO Rep
. 2020 Feb;
21(3):e49129.
PMID: 32030864
Signalling endosomes are essential for trafficking of activated ligand-receptor complexes and their distal signalling, ultimately leading to neuronal survival. Although deficits in signalling endosome transport have been linked to neurodegeneration,...
5.
Sleigh J, Rossor A, Fellows A, Tosolini A, Schiavo G
Nat Rev Neurol
. 2019 Sep;
15(12):691-703.
PMID: 31558780
Axonal transport is the process whereby motor proteins actively navigate microtubules to deliver diverse cargoes, such as organelles, from one end of the axon to the other, and is widely...
6.
Gibbs K, Kalmar B, Rhymes E, Fellows A, Ahmed M, Whiting P, et al.
Cell Death Dis
. 2018 May;
9(6):596.
PMID: 29789529
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease caused by the degeneration of upper and lower motor neurons. Defects in axonal transport have been observed pre-symptomatically in the SOD1...
7.
Surana S, Tosolini A, Meyer I, Fellows A, Novoselov S, Schiavo G
Toxicon
. 2017 Oct;
147:58-67.
PMID: 29031941
Tetanus (TeNT) and botulinum (BoNT) neurotoxins, the causative agents of tetanus and botulism, respectively, are the most potent toxic molecules known to mankind. This extreme potency is attributed to: i)...
8.
Paulin J, Haslehurst P, Fellows A, Liu W, Jackson J, Joel Z, et al.
Neural Plast
. 2016 Feb;
2016:6170509.
PMID: 26881123
The laying down of memory requires strong stimulation resulting in specific changes in synaptic strength and corresponding changes in size of dendritic spines. Strong stimuli can also be pathological, causing...
9.
Harries L, Fellows A, Pilling L, Hernandez D, Singleton A, Bandinelli S, et al.
Mech Ageing Dev
. 2012 Jul;
133(8):556-62.
PMID: 22813852
Interventions which inhibit TOR activity (including rapamycin and caloric restriction) lead to downstream gene expression changes and increased lifespan in laboratory models. However, the role of mTOR signaling in human...