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Alexander Brol

Explore the profile of Alexander Brol including associated specialties, affiliations and a list of published articles. Areas
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Recent Articles
1.
Towell H, Braun D, Brol A, di Fonzo A, Rijntjes E, Kohrle J, et al.
Biomolecules . 2024 Nov; 14(11). PMID: 39595550
Iodothyronine deiodinases (Dio) are selenocysteine-containing membrane enzymes that activate and inactivate the thyroid hormones (TH) through reductive iodide eliminations. The three deiodinase isoforms are homodimers sharing highly conserved amino acid...
2.
Rodriguez-Ruiz A, Braun D, Pflug S, Brol A, Sylvester M, Steegborn C, et al.
Int J Mol Sci . 2022 May; 23(10). PMID: 35628173
The three isoenzymes of iodothyronine deiodinases (DIO1-3) are membrane-anchored homo-dimeric selenoproteins which share the thioredoxin-fold structure. Several questions regarding their catalytic mechanisms still remain open. Here, we addressed the roles...