Alexander Bondke
Overview
Explore the profile of Alexander Bondke including associated specialties, affiliations and a list of published articles.
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Articles
4
Citations
73
Followers
0
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Recent Articles
1.
Cushing V, Koh A, Feng J, Jurgaityte K, Bondke A, Kroll S, et al.
Nat Commun
. 2024 Mar;
15(1):2265.
PMID: 38480681
Rational design of next-generation therapeutics can be facilitated by high-resolution structures of drug targets bound to small-molecule inhibitors. However, application of structure-based methods to macromolecules refractory to crystallization has been...
2.
Patel H, Periyasamy M, Sava G, Bondke A, Slafer B, Kroll S, et al.
Mol Cancer Ther
. 2018 Mar;
17(6):1156-1166.
PMID: 29545334
Recent reports indicate that some cancer types are especially sensitive to transcription inhibition, suggesting that targeting the transcriptional machinery provides new approaches to cancer treatment. Cyclin-dependent kinase (CDK)7 is necessary...
3.
Hazel P, Kroll S, Bondke A, Barbazanges M, Patel H, Fuchter M, et al.
ChemMedChem
. 2018 Jan;
13(2):207.
PMID: 29372749
No abstract available.
4.
Hazel P, Kroll S, Bondke A, Barbazanges M, Patel H, Fuchter M, et al.
ChemMedChem
. 2017 Jan;
12(5):372-380.
PMID: 28125165
Deregulation of the cell cycle by mechanisms that lead to elevated activities of cyclin-dependent kinases (CDK) is a feature of many human diseases, cancer in particular. We identified small-molecule inhibitors...