Alexander B Chase
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Explore the profile of Alexander B Chase including associated specialties, affiliations and a list of published articles.
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27
Citations
344
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Recent Articles
1.
Sweeney D, Bogdanov A, Chase A, Castro-Falcon G, Trinidad-Javier A, Dahesh S, et al.
J Nat Prod
. 2024 Nov;
87(12):2768-2778.
PMID: 39575834
Terrestrial actinomycetes in the genus have long been recognized as prolific producers of small-molecule natural products, including many clinically important antibiotics and cytotoxic agents. Although can also be isolated from...
2.
Sweeney D, Bogdanov A, Chase A, Castro-Falcon G, Trinidad-Javier A, Dahesh S, et al.
bioRxiv
. 2024 Nov;
PMID: 39554111
Terrestrial actinomycetes in the genus have long been recognized as prolific producers of small molecule natural products, including many clinically important antibiotics and cytotoxic agents. Although can also be isolated...
3.
Substrate complexity buffers negative interactions in a synthetic community of leaf litter degraders
Abdoli P, Vulin C, Lepiz M, Chase A, Weihe C, Rodriguez-Verdugo A
FEMS Microbiol Ecol
. 2024 Jul;
100(8).
PMID: 39020097
Leaf litter microbes collectively degrade plant polysaccharides, influencing land-atmosphere carbon exchange. An open question is how substrate complexity-defined as the structure of the saccharide and the amount of external processing...
4.
Small molecule in situ resin capture provides a compound first approach to natural product discovery
Bogdanov A, Salib M, Chase A, Hammerlindl H, Muskat M, Luedtke S, et al.
Nat Commun
. 2024 Jun;
15(1):5230.
PMID: 38898025
Culture-based microbial natural product discovery strategies fail to realize the extraordinary biosynthetic potential detected across earth's microbiomes. Here we introduce Small Molecule In situ Resin Capture (SMIRC), a culture-independent method...
5.
Abs E, Chase A, Manzoni S, Ciais P, Allison S
Glob Chang Biol
. 2024 Apr;
30(4):e17268.
PMID: 38562029
Although substantial advances in predicting the ecological impacts of global change have been made, predictions of the evolutionary impacts have lagged behind. In soil ecosystems, microbes act as the primary...
6.
Sweeney D, Chase A, Bogdanov A, Jensen P
J Nat Prod
. 2024 Feb;
87(2):439-452.
PMID: 38353658
Marine-derived have long been recognized as a source of novel, pharmaceutically relevant natural products. Among these bacteria, the MAR4 clade within the genus has been identified as metabolically rich, yielding...
7.
Bogdanov A, Salib M, Chase A, Hammerlindl H, Muskat M, Luedtke S, et al.
bioRxiv
. 2023 Jul;
PMID: 37398257
Microbial natural products remain an important resource for drug discovery. Yet, commonly employed discovery techniques are plagued by the rediscovery of known compounds, the relatively few microbes that can be...
8.
Singh H, Creamer K, Chase A, Klau L, Podell S, Jensen P
mSystems
. 2023 Jun;
8(3):e0001223.
PMID: 37272717
Microbial polyketide synthase (PKS) genes encode the biosynthesis of many biomedically or otherwise commercially important natural products. Despite extensive discovery efforts, metagenomic analyses suggest that only a small fraction of...
9.
Chase A, Bogdanov A, Demko A, Jensen P
ISME J
. 2023 Apr;
17(7):976-983.
PMID: 37061583
While the field of microbial biogeography has largely focused on the contributions of abiotic factors to community patterns, the potential influence of biotic interactions in structuring microbial communities, such as...
10.
Martiny J, Martiny A, Brodie E, Chase A, Rodriguez-Verdugo A, Treseder K, et al.
Ecol Lett
. 2023 Mar;
26 Suppl 1:S81-S90.
PMID: 36965002
Microorganisms are the primary engines of biogeochemical processes and foundational to the provisioning of ecosystem services to human society. Free-living microbial communities (microbiomes) and their functioning are now known to...