Alexander Aivazidis
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Explore the profile of Alexander Aivazidis including associated specialties, affiliations and a list of published articles.
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7
Citations
456
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Recent Articles
1.
Lee J, Barnett S, Roberts K, Ashwin H, Milross L, Cho J, et al.
Nat Commun
. 2025 Mar;
16(1):1979.
PMID: 40064844
The most common cause of death due to COVID-19 remains respiratory failure. Yet, our understanding of the precise cellular and molecular changes underlying lung alveolar damage is limited. Here, we...
2.
Aivazidis A, Memi F, Kleshchevnikov V, Er S, Clarke B, Stegle O, et al.
Nat Methods
. 2025 Mar;
PMID: 40032996
RNA velocity exploits the temporal information contained in spliced and unspliced RNA counts to infer transcriptional dynamics. Existing velocity models often rely on coarse biophysical simplifications or numerical approximations to...
3.
Reitman M, Tse V, Mi X, Willoughby D, Peinado A, Aivazidis A, et al.
Nat Neurosci
. 2023 Mar;
26(4):579-593.
PMID: 36997759
Cortical state, defined by population-level neuronal activity patterns, determines sensory perception. While arousal-associated neuromodulators-including norepinephrine (NE)-reduce cortical synchrony, how the cortex resynchronizes remains unknown. Furthermore, general mechanisms regulating cortical synchrony...
4.
Bulstrode H, Girdler G, Gracia T, Aivazidis A, Moutsopoulos I, Young A, et al.
Neuron
. 2022 Sep;
110(23):3936-3951.e10.
PMID: 36174572
Zika virus (ZIKV) can infect human developing brain (HDB) progenitors resulting in epidemic microcephaly, whereas analogous cellular tropism offers treatment potential for the adult brain cancer, glioblastoma (GBM). We compared...
5.
Kleshchevnikov V, Shmatko A, Dann E, Aivazidis A, King H, Li T, et al.
Nat Biotechnol
. 2022 Jan;
40(5):661-671.
PMID: 35027729
Spatial transcriptomic technologies promise to resolve cellular wiring diagrams of tissues in health and disease, but comprehensive mapping of cell types in situ remains a challenge. Here we present сell2location,...
6.
Kuhre R, Ghiasi S, Adriaenssens A, Wewer Albrechtsen N, Andersen D, Aivazidis A, et al.
Diabetologia
. 2019 Mar;
62(6):1011-1023.
PMID: 30903205
Aims/hypothesis: Sodium-glucose cotransporter (SGLT) 2 inhibitors constitute a new class of glucose-lowering drugs, but they increase glucagon secretion, which may counteract their glucose-lowering effect. Previous studies using static incubation of...
7.
Skrtic S, Tyrberg B, Broberg M, Ericsson H, Schnecke V, Kjaer M, et al.
PLoS One
. 2018 Dec;
13(12):e0208998.
PMID: 30557325
Aims/hypothesis: GPR44 (DP2, PTGDR2, CRTh2) is the receptor for the pro-inflammatory mediator prostaglandin D2 (PGD2) and it is enriched in human islets. In rodent islets, PGD2 is produced in response...
8.
Ghiasi S, Dahllof M, Osmai Y, Osmai M, Jakobsen K, Aivazidis A, et al.
Mol Cell Endocrinol
. 2018 Aug;
478:106-114.
PMID: 30121202
β-Cells may be a source of IL-1β that is produced as inactive pro-IL-1β and processed into biologically-active IL-1β by enzymatic cleavage mediated by the NLRP1-, NLRP3- and NLRC4-inflammasomes. Little is...
9.
Diedisheim M, Oshima M, Albagli O, Wennberg Huldt C, Ahlstedt I, Clausen M, et al.
Mol Metab
. 2018 Feb;
10:74-86.
PMID: 29472102
Objective: Dedifferentiation could explain reduced functional pancreatic β-cell mass in type 2 diabetes (T2D). Methods: Here we model human β-cell dedifferentiation using growth factor stimulation in the human β-cell line,...