Alexander A Khromykh
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Explore the profile of Alexander A Khromykh including associated specialties, affiliations and a list of published articles.
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Articles
131
Citations
5075
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Recent Articles
1.
Skin patch delivery of a SARS-CoV-2 spike DNA vaccine produces broad neutralising antibody responses
McMillan C, Corner A, Wijesundara D, Choo J, Pittayakhajonwut D, Poredi I, et al.
Heliyon
. 2025 Mar;
11(4):e42533.
PMID: 40034315
The ongoing SARS-CoV-2 pandemic continues to be a major health burden globally, especially in resource-limited areas. Continued research into more effective and accessible vaccines is required to reduce the burden...
2.
Reuter M, Parry R, McDonald M, Gestuveo R, Arif R, Khromykh A, et al.
RNA
. 2025 Feb;
PMID: 39947927
The exogenous siRNA (exo-siRNA) pathway is a critical RNA interference response involved in controlling arbovirus replication in mosquito cells. It is initiated by the detection of viral long double-stranded RNA...
3.
Goh J, de Hayr L, Khromykh A, Slonchak A
Vaccines (Basel)
. 2024 Aug;
12(8).
PMID: 39203991
Flaviviruses, including dengue (DENV), Zika (ZIKV), West Nile (WNV), Japanese encephalitis (JEV), yellow fever (YFV), and tick-borne encephalitis (TBEV) viruses, pose a significant global emerging threat. With their potential to...
4.
Shaker M, Slonchak A, Al-Mhanawi B, Morrison S, Sng J, Cooper-White J, et al.
Sci Adv
. 2024 Jun;
10(23):eadj4735.
PMID: 38838150
Why individuals with Down syndrome (DS) are more susceptible to SARS-CoV-2-induced neuropathology remains elusive. Choroid plexus (ChP) plays critical roles in barrier function and immune response modulation and expresses the...
5.
Wang L, Cheng Q, Newton N, Wolfinger M, Morgan M, Slonchak A, et al.
J Gen Virol
. 2024 May;
105(5).
PMID: 38809251
Tick-borne orthoflaviviruses (TBFs) are classified into three conventional groups based on genetics and ecology: mammalian, seabird and probable-TBF group. Recently, a fourth basal group has been identified in ticks from...
6.
Peng N, Sng J, Setoh Y, Khromykh A
Microorganisms
. 2024 Apr;
12(4).
PMID: 38674605
The identification of four potential nonstructural 5 (NS5) residues-K28, K45, V335, and S749-that share the same amino acid preference in STAT2-interacting flaviviruses [Dengue virus (DENV) and Zika virus (ZIKV)], but...
7.
McMillan C, Wijesundara D, Choo J, Amarilla A, Modhiran N, Fernando G, et al.
J Gen Virol
. 2024 Jan;
105(1).
PMID: 38271027
The COVID-19 pandemic has highlighted the need for vaccines capable of providing rapid and robust protection. One way to improve vaccine efficacy is delivery via microarray patches, such as the...
8.
Stewart R, Yan K, Ellis S, Bishop C, Dumenil T, Tang B, et al.
Front Microbiol
. 2023 Dec;
14:1320856.
PMID: 38075874
The reduced pathogenicity of the omicron BA.1 sub-lineage compared to earlier variants is well described, although whether such attenuation is retained for later variants like BA.5 and XBB remains controversial....
9.
Parry R, Slonchak A, Campbell L, Newton N, Debat H, Gifford R, et al.
J Gen Virol
. 2023 Dec;
104(12).
PMID: 38059479
Flavivirids are small, enveloped, positive-sense RNA viruses from the family with genomes of ~9-13 kb. Metatranscriptomic analyses of metazoan organisms have revealed a diversity of flavivirus-like or flavivirid viral sequences...
10.
Pegg C, Modhiran N, Parry R, Liang B, Amarilla A, Khromykh A, et al.
Glycobiology
. 2023 Dec;
34(2).
PMID: 38048640
The emergence of SARS-CoV-2 variants alters the efficacy of existing immunity towards the viral spike protein, whether acquired from infection or vaccination. Mutations that impact N-glycosylation of spike may be...