Alex Zacharek
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Explore the profile of Alex Zacharek including associated specialties, affiliations and a list of published articles.
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80
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2421
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Recent Articles
1.
Gao H, Liu X, Venkat P, Findeis E, Zacharek A, Powell B, et al.
Front Neurosci
. 2024 Jul;
18:1408205.
PMID: 39050669
Background: Vascular dementia (VaD) is a complex neurodegenerative disorder. We previously found that treatment of VaD in middle-aged male rats subjected to multiple microinfarction (MMI) with AV-001, a Tie2 receptor...
2.
Morris D, Zacharek A, Zhang Z, Chopp M
Addict Biol
. 2023 Nov;
28(12):e13353.
PMID: 38017641
Opioid use disorder (OUD) is a growing health emergency in the United States leading to an epidemic of overdose deaths. OUD is recognized as an addictive brain disorder resulting in...
3.
Gao H, Findeis E, Culmone L, Powell B, Landschoot-Ward J, Zacharek A, et al.
Front Aging Neurosci
. 2023 Jun;
15:1180913.
PMID: 37304071
Background: Vascular Dementia (VaD) refers to dementia caused by cerebrovascular disease and/or reduced blood flow to the brain and is the second most common form of dementia after Alzheimer's disease....
4.
Venkat P, Gao H, Findeis E, Chen Z, Zacharek A, Landschoot-Ward J, et al.
Front Neurosci
. 2023 Mar;
17:1061485.
PMID: 36968490
Background And Purpose: Non-alcoholic fatty liver disease (NAFLD) is known to adversely affect stroke recovery. However, few studies investigate how stroke elicits liver dysfunction, particularly, how stroke in type 2...
5.
Culmone L, Powell B, Landschoot-Ward J, Zacharek A, Gao H, Findeis E, et al.
Front Cell Neurosci
. 2022 May;
16:869710.
PMID: 35602559
Background And Purpose: Vascular dementia (VaD) is a complex neurodegenerative disease affecting cognition and memory. There is a lack of approved pharmacological treatments specifically for VaD. In this study, we...
6.
Zhou M, Li R, Venkat P, Qian Y, Chopp M, Zacharek A, et al.
Front Neurol
. 2022 May;
13:863934.
PMID: 35572941
Patients with type 2 diabetes mellitus (T2DM) exhibit a distinct and high risk of ischemic stroke with worse post-stroke neurovascular and white matter (WM) prognosis than the non-diabetic population. In...
7.
An L, Chopp M, Zacharek A, Shen Y, Chen Z, Qian Y, et al.
Front Cardiovasc Med
. 2021 Jun;
8:681572.
PMID: 34179145
Cardiac function is associated with cognitive function. Previously, we found that stroke and traumatic brain injury evoke cardiac dysfunction in mice. In this study, we investigate whether bilateral common carotid...
8.
An L, Shen Y, Chopp M, Zacharek A, Venkat P, Chen Z, et al.
Aging Dis
. 2021 Jun;
12(3):732-746.
PMID: 34094639
Vascular Dementia (VaD) accounts for nearly 20% of all cases of dementia. eNOS plays an important role in neurovascular remodeling, anti-inflammation, and cognitive functional recovery after stroke. In this study,...
9.
Venkat P, Ning R, Zacharek A, Culmone L, Liang L, Landschoot-Ward J, et al.
CNS Neurosci Ther
. 2020 Dec;
27(1):48-59.
PMID: 33346402
Aim: Vasculotide (VT), an angiopoietin-1 mimetic peptide, exerts neuroprotective effects in type one diabetic (T1DM) rats subjected to ischemic stroke. In this study, we investigated whether delayed VT treatment improves...
10.
Venkat P, Culmone L, Chopp M, Landschoot-Ward J, Wang F, Zacharek A, et al.
Front Aging Neurosci
. 2020 Sep;
12:258.
PMID: 32973489
: Vascular dementia (VaD) is the second common cause of dementia after Alzheimer's disease in older people. Yet, there are no FDA approved drugs specifically for VaD. In this study,...