Alex Shimura Yamashita
Overview
Explore the profile of Alex Shimura Yamashita including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
343
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0
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Recent Articles
1.
ERK signaling promotes resistance to TRK kinase inhibition in NTRK fusion-driven glioma mouse models
Schmid S, Russell Z, Yamashita A, West M, Parrish A, Walker J, et al.
Cell Rep
. 2024 Oct;
43(10):114829.
PMID: 39365700
Pediatric-type high-grade gliomas frequently harbor gene fusions involving receptor tyrosine kinase genes, including neurotrophic tyrosine kinase receptor (NTRK) fusions. Clinically, these tumors show high initial response rates to tyrosine kinase...
2.
ERK signaling promotes resistance to TRK kinase inhibition in NTRK fusion-driven glioma mouse models
Schmid S, Russell Z, Yamashita A, West M, Parrish A, Walker J, et al.
bioRxiv
. 2024 Apr;
PMID: 38558981
Pediatric-type high-grade gliomas frequently harbor gene fusions involving receptor tyrosine kinase genes, including neurotrophic tyrosine kinase receptor (NTRK) fusions. Clinically, these tumors show high initial response rates to tyrosine kinase...
3.
da Costa Rosa M, Yamashita A, Riggins G
Neuro Oncol
. 2021 Dec;
24(5):711-723.
PMID: 34850159
Background: Isocitrate Dehydrogenase 1/2 (IDH1/2) mutations are diagnostic for Astrocytoma or Oligodendroglioma, IDH-mutant. In these IDH-mutant gliomas, retinoic acid-related gene expression is commonly silenced by DNA hypermethylation. DNA demethylating agents...
4.
Yamashita A, da Costa Rosa M, Stumpo V, Rais R, Slusher B, Riggins G
Neurooncol Adv
. 2021 Mar;
3(1):vdaa149.
PMID: 33681764
Background: Metabolic reprogramming is a common feature in cancer, and it is critical to facilitate cancer cell growth. and mutations (mut) are the most common genetic alteration in glioma grade...
5.
Goncalves D, Lira F, Yamashita A, Carnevali Junior L, Eder R, Laviano A, et al.
Clin Nutr
. 2018 Oct;
38(5):2219-2230.
PMID: 30322784
Background & Aims: The liver is the main organ regulating metabolism. In spite of that, few studies examine liver metabolism in cachexia, a wasting syndrome associated with increased morbidity and...
6.
Yamashita A, da Costa Rosa M, Borodovsky A, Festuccia W, Chan T, Riggins G
Neuro Oncol
. 2018 Sep;
21(2):189-200.
PMID: 30184215
Background: Isocitrate deyhydrogenase (IDH) mutant glioma comprises the majority of grades II-III gliomas and nearly all secondary glioblastomas. These progressive gliomas arise from mutations in IDH1 or IDH2 that pathologically...
7.
Fort R, Matho C, Geraldo M, Ottati M, Yamashita A, Saito K, et al.
BMC Cancer
. 2018 Feb;
18(1):127.
PMID: 29394925
Background: Nc886 is a 102 bp non-coding RNA transcript initially classified as a microRNA precursor (Pre-miR-886), later as a divergent homologue of the vault RNAs (vtRNA 2-1) and more recently...
8.
de Lima Junior E, Yamashita A, Pimentel G, de Sousa L, Santos R, Goncalves C, et al.
J Cachexia Sarcopenia Muscle
. 2016 May;
7(5):615-625.
PMID: 27239415
Background: Cancer is considered the second leading cause of death in the world, and for the treatment of this disease, pharmacological intervention strategies are frequently based on chemotherapy. Doxorubicin (DOX)...
9.
White adipose tissue IFN-γ expression and signalling along the progression of rodent cancer cachexia
Yamashita A, Xavier das Neves R, Rosa-Neto J, Lira F, Batista Jr M, Alcantara P, et al.
Cytokine
. 2016 Mar;
89:122-126.
PMID: 26987263
Cachexia is associated with increased morbidity and mortality in cancer. The White adipose tissue (WAT) synthesizes and releases several pro-inflammatory cytokines that play a role in cancer cachexia-related systemic inflammation....
10.
Yamashita A, Geraldo M, Fuziwara C, Kulcsar M, Friguglietti C, da Costa R, et al.
Transl Oncol
. 2013 Apr;
6(2):197-205.
PMID: 23544172
Mutually exclusive genetic alterations in the RET, RAS, or BRAF genes, which result in constitutively active mitogen-activated protein kinase (MAPK) signaling, are present in about 70% of papillary thyroid carcinomas...