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Alex Rafacho

Explore the profile of Alex Rafacho including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 72
Citations 697
Followers 0
Related Specialties
Endocrinology
Physiology
Biochemistry
Top 10 Co-Authors
Antonio C Boschero
Ivan Quesada
Cristiane Dos Santos
Everardo M Carneiro
Angel Nadal
Jose R Bosqueiro
Antonio Carlos Boschero
Sebastiao Roberto Taboga
Laura Marroqui
Jose Roberto Bosqueiro
Published In
Life Sci
J Steroid Biochem Mol Biol
Int J Exp Pathol
J Endocrinol
Endocrinology
Affiliations
Soon will be listed here.
Recent Articles
1.
Twenty-four weeks of combined training in different environments, aquatic and land, in the type 2 diabetes management (Aquatic and Land Exercise for Diabetes -ALED): protocol of a randomized clinical trial
Leonel L, Wolin I, Danielevicz A, Diesel M, Constantini M, de Oliveira Junior J, et al.
Trials . 2025 Jan; 26(1):12. PMID: 39780268
Background: Physical exercise is crucial in type 2 diabetes management (T2D), and training in the aquatic environment seems to be a promising alternative due to its physical properties and metabolic,...
2.
Hepatocyte nuclear factor 4-α is necessary for high fat diet-induced pancreatic β-cell mass expansion and metabolic compensations
de Ramos F, Barth R, Santos M, Almeida M, Ferreira S, Rafacho A, et al.
Front Endocrinol (Lausanne) . 2025 Jan; 15:1511813. PMID: 39741884
Aims: This study investigates the role of Hepatocyte Nuclear Factor 4α (HNF4α) in the adaptation of pancreatic β-cells to an HFD-induced obesogenic environment, focusing on β cell mass expansion and...
3.
Hyperglucagonemia and glucagon hypersecretion in early type 2 diabetes result from multifaceted dysregulation of pancreatic mouse α-cells
Ruiz-Pino A, Goncalves-Ramirez A, Jimenez-Palomares M, Merino B, Castellano-Munoz M, Vettorazzi J, et al.
Pflugers Arch . 2024 Nov; 477(2):207-221. PMID: 39601887
Hyperglucagonemia has been implicated in the pathogenesis of type 2 diabetes (T2D). In contrast to β-cells, studies on the function of the pancreatic α-cell in T2D are scarce. Consequently, the...
4.
Moderate chronic sleep perturbation impairs glucose and lipid homeostasis in rats
Tonet N, da Silva Marcal D, da Silva F, Brunetta H, Mori M, Dos Santos G, et al.
Sleep . 2024 May; 47(7). PMID: 38788154
Study Objectives: Sleep deprivation is a potential risk factor for metabolic diseases, including obesity and type 2 diabetes. We evaluated the impacts of moderate chronic sleep deprivation on glucose and...
5.
Zein nanoparticles as oral carrier for mometasone furoate delivery
Zimath P, Pinto S, Dias S, Rafacho A, Sarmento B
Drug Deliv Transl Res . 2023 May; 13(11):2948-2959. PMID: 37208563
Mometasone furoate (MF) is a synthetic glucocorticoid used clinically to treat specific inflammatory disorders including superior and inferior respiratory tract. Due to its poor bioavailability we further investigated whether nanoparticles...
6.
Coadministration of olanzapine causes minor impacts on the diabetogenic outcomes induced by dexamethasone treatment in rats
da Silva F, Zimath P, do Amaral T, Martins J, Rafacho A
Life Sci . 2023 Apr; 322:121660. PMID: 37011876
Aims: Investigate whether the coadministration of olanzapine exacerbates the diabetogenic effects of dexamethasone, two agents used in the antiemetic cocktails indicated to mitigate the adverse effects of chemotherapy. Main Methods:...
7.
Oral mometasone furoate administration preserves anti-inflammatory action with fewer metabolic adverse effects in rats
Zimath P, Almeida M, Bruxel M, Rafacho A
Biochem Pharmacol . 2023 Mar; 210:115486. PMID: 36893817
Background: Exogenous glucocorticoids (CGs) possess relevant therapeutic effects but exert diabetogenic actions when in excess. Thus, ligands with potential therapeutic applications and fewer adverse effects are needed. To this, we...
8.
Preconception exposure to malathion and glucose homeostasis in rats: Effects on dams during pregnancy and post-term periods, and on their progeny
Bruxel M, da Silva F, da Silva R, Zimath P, Rojas A, Moreira E, et al.
Environ Pollut . 2022 Nov; 316(Pt 2):120633. PMID: 36370973
Understanding the individual and global impact of pesticides on human physiology and the different stages of life is still a challenge in environmental health. We analyzed here whether administration of...
9.
Glucocorticoids and glucolipotoxicity alter the DNA methylome and function of human EndoC-βH1 cells
Dos Santos C, Karagiannopoulos A, Rafacho A, Perfilyev A, Eliasson L, Ling C, et al.
Life Sci . 2022 Aug; 307:120854. PMID: 35917939
Aims: Synthetic glucocorticoids, including dexamethasone (DEX), are clinically prescribed due to their immunoregulatory properties. In excess they can perturb glucose homeostasis, with individuals predisposed to glucose intolerance more sensitive to...
10.
The effects of macronutrients composition on hormones and substrates during a meal tolerance test in drugnaive and sitagliptin-treated individuals with type 2 diabetes: a randomized crossover study
da Silva Schreiber C, Rafacho A, Silverio R, Betti R, Lerario A, Lotenberg A, et al.
Arch Endocrinol Metab . 2022 May; 66(3):312-323. PMID: 35551683
Objective: To evaluate the effect of sitagliptin treatment in early type 2 diabetes mellitus (T2DM) and the impact of different macronutrient compositions on hormones and substrates during meal tolerance tests...