Alex L Wilkinson
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Explore the profile of Alex L Wilkinson including associated specialties, affiliations and a list of published articles.
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14
Citations
130
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Recent Articles
1.
Wilkinson A, Bannister M, OKeeffe A, Weston C, Lalor P, Shetty S, et al.
STAR Protoc
. 2024 Nov;
5(4):103431.
PMID: 39504247
Modeling immune cell recruitment by liver endothelial cells in vitro is important to better understand the pathology of chronic inflammatory liver diseases and cancers. Here, we present a protocol for...
2.
Kennedy J, Davies S, Hewett P, Wilkinson A, Oo Y, Lu W, et al.
Front Cell Dev Biol
. 2024 May;
12:1359451.
PMID: 38694823
Immunotherapy has changed the landscape of treatment options for patients with hepatocellular cancer. Checkpoint inhibitors are now standard of care for patients with advanced tumours, yet the majority remain resistant...
3.
Wilkinson A, Hulme S, Kennedy J, Mann E, Horn P, Shepherd E, et al.
iScience
. 2023 Oct;
26(10):107966.
PMID: 37810232
Liver sinusoidal endothelial cells (LSEC) undergo significant phenotypic change in chronic liver disease (CLD), and yet the factors that drive this process and the impact on their function as a...
4.
Onyishi C, Desanti G, Wilkinson A, Lara-Reyna S, Frickel E, Fejer G, et al.
Nat Commun
. 2023 Aug;
14(1):4895.
PMID: 37580395
The opportunistic fungal pathogen Cryptococcus neoformans causes lethal infections in immunocompromised patients. Macrophages are central to the host response to cryptococci; however, it is unclear how C. neoformans is recognised...
5.
Patten D, Wilkinson A, OKeeffe A, Shetty S
Semin Liver Dis
. 2021 Nov;
42(1):e1.
PMID: 34794183
No abstract available.
6.
Wilkinson A, John A, Barrett J, Gower E, Morrison V, Man Y, et al.
Eur J Pharmacol
. 2021 Nov;
913:174618.
PMID: 34762934
Fibrosis is the formation of scar tissue due to injury or long-term inflammation and is a leading cause of morbidity and mortality. Activation of the pro-fibrotic cytokine transforming growth factor-β...
7.
Zaki M, Shetty S, Wilkinson A, Patten D, Oakley F, Reeves H
J Vis Exp
. 2021 Oct;
(175).
PMID: 34661571
The aggressiveness and lack of well-tolerated and widely effective treatments for advanced hepatocellular carcinoma (HCC), the predominant form of liver cancer, rationalize its rank as the second most common cause...
8.
Patten D, Wilkinson A, OKeeffe A, Shetty S
Semin Liver Dis
. 2021 Sep;
42(1):61-76.
PMID: 34553345
The scavenger receptor superfamily represents a highly diverse collection of evolutionarily-conserved receptors which are known to play key roles in host homeostasis, the most prominent of which is the clearance...
9.
Patten D, Wilkinson A, ORourke J, Shetty S
Front Oncol
. 2021 Aug;
10:565950.
PMID: 34354939
Scavenger receptor class F member 1 (SCARF1) is thought to play an important role in the selective recruitment of CD4 T cells to liver sinusoidal endothelial cells during chronic liver...
10.
Roper J, Wilkinson A, Gower E, Slack R
J Pharmacol Exp Ther
. 2020 Dec;
376(2):273-280.
PMID: 33318076
The arginyl-glycinyl-aspartic acid (RGD) integrin alpha-v beta-6 (v6) has been identified as playing a key role in the activation of transforming growth factor- (TGF) that is hypothesized to be pivotal...