Alex Kleinjan
Overview
Explore the profile of Alex Kleinjan including associated specialties, affiliations and a list of published articles.
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43
Citations
1335
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Recent Articles
1.
Grandi A, Ferrini E, Mecozzi L, Ciccimarra R, Zoboli M, Leo L, et al.
Am J Physiol Lung Cell Mol Physiol
. 2023 Jan;
324(2):L211-L227.
PMID: 36625471
The development of new drugs for idiopathic pulmonary fibrosis strongly relies on preclinical experimentation, which requires the continuous improvement of animal models and integration with in vivo imaging data. Here,...
2.
Beute J, Kleinjan A
Int J Pediatr Adolesc Med
. 2022 Jun;
9(2):147-151.
PMID: 35663792
In the last two decades, improvement on asthma treatment has been merely marginal for both adults and children; inhaled corticosteroids (ICS) combined with β-2-mimetics remain the main therapy [3,4]. "New"...
3.
4.
Beute J, Boermans P, Kleinjan A
Can Respir J
. 2021 Nov;
2021:7456208.
PMID: 34760031
Background: The population of uncontrolled asthma patients represents a large therapeutic burden. The PDE3-inhibitor enoximone is a strong and quick bronchodilator and is known to successfully treat life-threatening bronchial asthma...
5.
Ravanetti F, Ferrini E, Ragionieri L, Khalajzeyqami Z, Nicastro M, Ridwan Y, et al.
Sci Rep
. 2021 Sep;
11(1):18513.
PMID: 34531421
Systemic sclerosis (SSc) is an autoimmune disease characterized by an excessive production and accumulation of collagen in the skin and internal organs often associated with interstitial lung disease (ILD). Its...
6.
van de Wouw J, Steenhorst J, Sorop O, van Drie R, Wielopolski P, Kleinjan A, et al.
Basic Res Cardiol
. 2021 Sep;
116(1):51.
PMID: 34510273
Pulmonary hypertension is common in heart failure with preserved ejection fraction (HFpEF). Here, we tested the hypothesis that comorbidities [diabetes mellitus (DM, streptozotocin), hypercholesterolemia (HC, high-fat diet) and chronic kidney...
7.
Beute J, Kleinjan A
J Aerosol Med Pulm Drug Deliv
. 2021 Sep;
34(5):322-323.
PMID: 34495768
No abstract available.
8.
Kleinjan A, van Nimwegen M, Leman K, Wen K, Boon L, Hendriks R
Mediators Inflamm
. 2021 May;
2021:8845966.
PMID: 34054347
Objective: To study airway pathophysiology and the role of dendritic cells (DCs) and IL-17 receptor (IL-17R) signals in a mouse model for CBD. Methods: Here, we present a CBD mouse...
9.
Beute J, Boermans P, Benraad B, Telman J, Diamant Z, Kleinjan A
Exp Lung Res
. 2021 Feb;
47(3):149-160.
PMID: 33544007
Background: Standard care in severe SARS-CoV-2 pneumonia complicated by severe dyspnea and respiratory failure, consists of symptom reduction, ultimately supported by mechanical ventilation. Patients with severe SARS-CoV-2, a prominent feature...
10.
Beute J, Ganesh K, Nastiti H, Hoogenboom R, Bos V, Folkerts J, et al.
Front Pharmacol
. 2020 May;
11:470.
PMID: 32425769
Epithelial mast cells are generally present in the airways of patients with allergic asthma that are inadequately controlled. Airway mast cells (MCs) are critically involved in allergic airway inflammation and...