Alex K Harris
Overview
Explore the profile of Alex K Harris including associated specialties, affiliations and a list of published articles.
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10
Citations
494
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Recent Articles
1.
Kelly-Cobbs A, Harris A, Elgebaly M, Li W, Sachidanandam K, Portik-Dobos V, et al.
J Pharmacol Exp Ther
. 2011 Jan;
337(1):9-15.
PMID: 21205912
Structure and function of the cerebrovasculature is critical for ischemic stroke outcome. We showed that diabetes causes cerebrovascular remodeling by activation of the endothelin A (ET(A)) receptors. The goal of...
2.
Elgebaly M, Kelly A, Harris A, Elewa H, Portik-Dobos V, Ketsawatsomkron P, et al.
Can J Physiol Pharmacol
. 2008 Jun;
86(6):358-64.
PMID: 18516099
Insulin resistance involves decreased phosphorylation of insulin receptor substrate (IRS) proteins and (or) Akt. In the vasculature, modulated Akt phosphorylation may cause impaired vasorelaxation via decreased eNOS activation. Diet-induced insulin...
3.
Sachidanandam K, Elgebaly M, Harris A, Hutchinson J, Mezzetti E, Portik-Dobos V, et al.
Am J Physiol Heart Circ Physiol
. 2008 Apr;
294(6):H2743-9.
PMID: 18424628
Vascular dysfunction, which presents either as an increased response to vasoconstrictors or an impaired relaxation to dilator agents, results in worsened cardiovascular outcomes in diabetes. We have established that the...
4.
Harris A, Elgebaly M, Li W, Sachidanandam K, Ergul A
Am J Physiol Regul Integr Comp Physiol
. 2008 Feb;
294(4):R1213-9.
PMID: 18287215
Diabetes increases the risk of stroke and contributes to poor clinical outcomes in this patient population. Myogenic tone of the cerebral vasculature, including basilar arteries, plays a key role in...
5.
Sachidanandam K, Portik-Dobos V, Harris A, Hutchinson J, Muller E, Johnson M, et al.
Diabetes
. 2007 Aug;
56(11):2753-8.
PMID: 17670915
Objective: Vascular remodeling, characterized by extracellular matrix deposition and increased media-to-lumen (M/l) ratio, contributes to the development of microvascular complications in diabetes. Matrix metalloproteinases (MMPs) play an important role in...
6.
Portik-Dobos V, Harris A, Song W, Hutchinson J, Johnson M, Imig J, et al.
Am J Physiol Regul Integr Comp Physiol
. 2005 Oct;
290(2):R435-41.
PMID: 16239374
Although past studies have demonstrated decreased renal matrix metalloproteinase (MMP) activity in type 1 diabetes and in mesangial cells grown under high glucose conditions, renal MMP expression and activity in...
7.
Harris A, Hutchinson J, Sachidanandam K, Johnson M, Dorrance A, Stepp D, et al.
Diabetes
. 2005 Aug;
54(9):2638-44.
PMID: 16123352
The risk of cerebrovascular disease is four- to sixfold higher in patients with diabetes. Vascular remodeling, characterized by extracellular matrix deposition and an increased media-to-lumen ratio, occurs in diabetes and...
8.
Harris A, Ergul A, Kozak A, Machado L, Johnson M, Fagan S
BMC Neurosci
. 2005 Aug;
6:49.
PMID: 16078993
Background: While gelatinase (MMP-2 and -9) activity is increased after focal ischemia/reperfusion injury in the brain, the relative contribution of neutrophils to the MMP activity and to the development of...
9.
Oxidative stress and the use of antioxidants in diabetes: linking basic science to clinical practice
Johansen J, Harris A, Rychly D, Ergul A
Cardiovasc Diabetol
. 2005 May;
4:5.
PMID: 15862133
Cardiovascular complications, characterized by endothelial dysfunction and accelerated atherosclerosis, are the leading cause of morbidity and mortality associated with diabetes. There is growing evidence that excess generation of highly reactive...
10.
Ergul A, Johansen J, Stromhaug C, Harris A, Hutchinson J, Tawfik A, et al.
J Pharmacol Exp Ther
. 2004 Dec;
313(1):70-7.
PMID: 15608082
Diabetes is associated with increased risk for complications following coronary bypass grafting (CABG) surgery. Augmented superoxide (*O2*) production plays an important role in diabetic complications by causing vascular dysfunction. The...