Alex J Whale
Overview
Explore the profile of Alex J Whale including associated specialties, affiliations and a list of published articles.
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5
Citations
30
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Recent Articles
1.
Hadjicharalambous A, Whale A, Can G, Skehel J, Houseley J, Zegerman P
Wellcome Open Res
. 2023 Sep;
8:327.
PMID: 37766847
In eukaryotes, replication stress activates a checkpoint response, which facilitates genome duplication by stabilising the replisome. How the checkpoint kinases regulate the replisome remains poorly understood. The aim of this...
2.
Zylstra A, Hadj-Moussa H, Horkai D, Whale A, Piguet B, Houseley J
PLoS Biol
. 2023 Aug;
21(8):e3002250.
PMID: 37643194
The massive accumulation of extrachromosomal ribosomal DNA circles (ERCs) in yeast mother cells has been long cited as the primary driver of replicative ageing. ERCs arise through ribosomal DNA (rDNA)...
3.
Horkai D, Hadj-Moussa H, Whale A, Houseley J
PLoS Biol
. 2023 Aug;
21(8):e3002245.
PMID: 37643155
Caloric restriction increases lifespan and improves ageing health, but it is unknown whether these outcomes can be separated or achieved through less severe interventions. Here, we show that an unrestricted...
4.
Whale A, King M, Hull R, Krueger F, Houseley J
Nucleic Acids Res
. 2022 Jan;
50(2):915-936.
PMID: 35018465
Adaptive mutations can cause drug resistance in cancers and pathogens, and increase the tolerance of agricultural pests and diseases to chemical treatment. When and how adaptive mutations form is often...
5.
Gal C, Murton H, Subramanian L, Whale A, Moore K, Paszkiewicz K, et al.
EMBO Rep
. 2015 Nov;
17(1):79-93.
PMID: 26582768
Maintenance of the correct level and organisation of nucleosomes is crucial for genome function. Here, we uncover a role for a conserved bromodomain AAA-ATPase, Abo1, in the maintenance of nucleosome...