Alex Castellarnau
Overview
Explore the profile of Alex Castellarnau including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
86
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Recent Articles
1.
Winchester S, Castellarnau A, Jabbar K, Nadir M, Ranasinghe K, Masramon X, et al.
Pharmaceutics
. 2024 Sep;
16(9).
PMID: 39339209
Background/objectives: Dendrimer-based astodrimer sodium nasal spray was assessed for its ability to reduce SARS-CoV-2 load in outpatients with COVID-19, which remains a severe illness for vulnerable groups. Methods: This was...
2.
Paull J, Luscombe C, Seta A, Heery G, Bobardt M, Gallay P, et al.
Sci Rep
. 2024 Sep;
14(1):21259.
PMID: 39261670
COVID-19 remains a severe condition for many including immunocompromised individuals. There remains a need for effective measures against this and other respiratory infections, which transmit via virus-laden droplets that reach...
3.
Castellarnau A, Heery G, Seta A, Luscombe C, Kinghorn G, Button P, et al.
Sci Rep
. 2022 Jun;
12(1):10210.
PMID: 35715644
Astodrimer sodium is a dendrimer molecule with antiviral and virucidal activity against SARS-CoV-2 and other respiratory viruses in vitro, and has previously been shown to be safe and well tolerated,...
4.
Paull J, Luscombe C, Castellarnau A, Heery G, Bobardt M, Gallay P
Viruses
. 2021 Aug;
13(8).
PMID: 34452519
Strategies to combat COVID-19 require multiple ways to protect vulnerable people from infection. SARS-CoV-2 is an airborne pathogen and the nasal cavity is a primary target of infection. The K18-hACE2...
5.
Paull J, Heery G, Bobardt M, Castellarnau A, Luscombe C, Fairley J, et al.
Antiviral Res
. 2021 May;
191:105089.
PMID: 34010661
An effective response to the ongoing coronavirus disease (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) will involve a range of complementary preventive modalities. The current studies...
6.
Schwebke J, Carter B, Waldbaum A, Agnew K, Paull J, Price C, et al.
Eur J Obstet Gynecol Reprod Biol X
. 2021 Feb;
10:100121.
PMID: 33537666
Objective: The objective of the study was to confirm the efficacy and safety of Astodrimer 1% Gel to prevent recurrence of bacterial vaginosis. Study Design: 864 women with a diagnosis...
7.
Waldbaum A, Schwebke J, Paull J, Price C, Edmondson S, Castellarnau A, et al.
PLoS One
. 2020 May;
15(5):e0232394.
PMID: 32365097
Background: Astodrimer Gel contains a novel dendrimer intended to treat and prevent bacterial vaginosis. We assessed the efficacy and safety of Astodrimer Gel for treatment of bacterial vaginosis. Methods: 132...
8.
Chavoustie S, Carter B, Waldbaum A, Donders G, Peters K, Schwebke J, et al.
Eur J Obstet Gynecol Reprod Biol
. 2019 Dec;
245:13-18.
PMID: 31812702
Objective: Astodrimer is a dendrimer formulated in a vaginal gel to treat bacterial vaginosis (BV) and prevent recurrence. The objective of these studies was to confirm the efficacy and safety...
9.
Castellarnau A, Werner M, Gunthner R, Jakob M
Kidney Int
. 2010 Jul;
78(9):920-5.
PMID: 20631678
Real-time determination of Kt/V can be provided by monitoring ultraviolet absorbance of solutes in spent dialysate. This not only overcomes dependency on error-prone pre- and post-dialysis blood sampling; it circumvents...