Alessandro Grattoni
Overview
Explore the profile of Alessandro Grattoni including associated specialties, affiliations and a list of published articles.
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90
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1105
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Recent Articles
1.
Conte M, Carofiglio M, Vander Pol R, Wood A, Hernandez N, Joubert A, et al.
ACS Appl Mater Interfaces
. 2025 Feb;
17(8):11873-11887.
PMID: 39960802
New treatment strategies are urgently needed for pancreatic ductal adenocarcinoma (PDAC), which is one of the deadliest tumors nowadays. PDAC is marked by hypoxia, intrinsic chemoresistance, a "cold" tumor microenvironment,...
2.
Capuani S, Hernandez N, Campa-Carranza J, Di Trani N, Yoshikawa T, Farina M, et al.
Biomaterials
. 2025 Jan;
317:123110.
PMID: 39824001
Contrasting findings are presented in the literature regarding the influence of foreign body response (FBR) on drug release from implantable drug delivery systems. To this end, here we sought direct...
3.
Facchi I, Di Trani N, Hernandez N, Joubert A, Wood A, Demarchi D, et al.
J Control Release
. 2024 Dec;
377:735-743.
PMID: 39626852
Interstitial fluid (IF) is pivotal in maintaining balance within tissues and organs, facilitating molecular transport and supporting homeostasis. Various drug delivery systems, such as long-acting depots or implants, rely on...
4.
Grattoni A, Korbutt G, Tomei A, Garcia A, Pepper A, Stabler C, et al.
Nat Rev Endocrinol
. 2024 Sep;
21(1):14-30.
PMID: 39227741
Type 1 diabetes mellitus (T1DM) is a growing global health concern that affects approximately 8.5 million individuals worldwide. T1DM is characterized by an autoimmune destruction of pancreatic β cells, leading...
5.
Kota N, Davila Gonzalez D, Liu H, Viswanath D, Vander Pol R, Wood A, et al.
Nanomedicine
. 2024 Aug;
62:102776.
PMID: 39102973
Selective in vivo immune cell manipulation offers a promising strategy for cancer vaccines. In this context, spatiotemporal control over recruitment of specific cells, and their direct exposure to appropriate immunoadjuvants...
6.
Bo T, Pascucci E, Capuani S, Campa-Carranza J, Franco L, Farina M, et al.
Biomed Microdevices
. 2024 Jun;
26(3):29.
PMID: 38888669
Subcutaneous delivery of cell therapy is an appealing minimally-invasive strategy for the treatment of various diseases. However, the subdermal site is poorly vascularized making it inadequate for supporting engraftment, viability,...
7.
Cho S, Malick H, Kim S, Grattoni A
J Invest Dermatol
. 2024 Mar;
144(8):1707-1715.
PMID: 38493383
Skin-on-a-chip (SoC) technologies are emerging as a paradigm shift in dermatology research by replicating human physiology in a dynamic manner not achievable by current animal models. Although animal models have...
8.
Chua C, Viswanath D, Huston D, Grattoni A
J Allergy Clin Immunol
. 2024 Jan;
153(3):572-575.
PMID: 38253261
Systemic immunotherapeutics have been a clinical staple in the treatment of cancer, infectious diseases, organ and cell transplantation, autoimmunity, and allergies. Although their utility remains unquestioned, systemic administration of these...
9.
Capuani S, Campa-Carranza J, Hernandez N, Chua C, Grattoni A
Adv Healthc Mater
. 2024 Jan;
14(5):e2304003.
PMID: 38215451
Cell delivery and encapsulation platforms are under development for the treatment of Type 1 Diabetes among other diseases. For effective cell engraftment, these platforms require establishing an immune-protected microenvironment as...
10.
Pons-Faudoa F, Di Trani N, Capuani S, Facchi I, Wood A, Nehete B, et al.
J Control Release
. 2023 Dec;
366:18-27.
PMID: 38142963
Treatment nonadherence is a pressing issue in people living with HIV (PLWH), as they require lifelong therapy to maintain viral suppression. Poor adherence leads to antiretroviral (ARV) resistance, transmission to...