Alessandro Bonifazi
Overview
Explore the profile of Alessandro Bonifazi including associated specialties, affiliations and a list of published articles.
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Articles
68
Citations
833
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Recent Articles
1.
Miciaccia M, Baldelli O, Fortuna C, Cavallaro G, Armenise D, Liturri A, et al.
J Med Chem
. 2025 Feb;
68(5):5190-5210.
PMID: 39973170
Pediatric diffuse intrinsic pontine glioma (DIPG), classified under diffuse midline glioma, is a deadly tumor, with no effective treatments. The human mitochondrial protease ClpP is a potential DIPG therapeutic target,...
2.
Arroyo-Urea S, Nazarova A, Carrion-Antoli A, Bonifazi A, Battiti F, Lam J, et al.
Nat Commun
. 2024 Sep;
15(1):7759.
PMID: 39237617
Although aminergic GPCRs are the target for ~25% of approved drugs, developing subtype selective drugs is a major challenge due to the high sequence conservation at their orthosteric binding site....
3.
Semeano A, Garland R, Bonifazi A, Lee K, Famiglietti J, Zhang W, et al.
ACS Pharmacol Transl Sci
. 2024 Aug;
7(8):2333-2349.
PMID: 39144557
Bitopic ligands bind both orthosteric and allosteric or secondary binding sites within the same receptor, often resulting in an improvement of receptor selectivity, potency, and efficacy. In particular, for both...
4.
Giorgioni G, Bonifazi A, Matucci R, Matteucci F, Piergentili A, Piergentili A, et al.
Arch Pharm (Weinheim)
. 2024 Jul;
357(10):e2400337.
PMID: 39054609
A new series of muscarinic acetylcholine receptor (mAChR) ligands obtained by inserting different substituents in position 2 of the potent 6,6-diphenyl-1,4-dioxane antagonists 4 and 5 was designed and synthesized to...
5.
Shen H, Ma Z, Hans E, Duan Y, Bi G, Chae Y, et al.
Neuropharmacology
. 2024 Jun;
257:110051.
PMID: 38917939
Impulsive decision-making has been linked to impulse control disorders and substance use disorders. However, the neural mechanisms underlying impulsive choice are not fully understood. While previous PET imaging and autoradiography...
6.
Bonifazi A, Ellenberger M, Farino Z, Aslanoglou D, Rais R, Pereira S, et al.
Diabetes
. 2024 Jun;
73(9):1411-1425.
PMID: 38869519
Article Highlights:
7.
Giorgioni G, Bonifazi A, Botticelli L, Cifani C, Matteucci F, Micioni Di Bonaventura E, et al.
Med Res Rev
. 2024 May;
44(6):2640-2706.
PMID: 38808959
5-HT1A receptor (5-HT1A-R) is a serotoninergic G-protein coupled receptor subtype which contributes to several physiological processes in both central nervous system and periphery. Despite being the first 5-HT-R identified, cloned...
8.
Bonifazi A, Ellenberger M, Farino Z, Aslanoglou D, Rais R, Pereira S, et al.
bioRxiv
. 2024 Mar;
PMID: 38529497
Dopamine (DA) D-like receptors in both the central nervous system (CNS) and the periphery are key modulators of metabolism. Moreover, disruption of D-like receptor signaling is implicated in dysglycemia. Yet,...
9.
Arroyo-Urea S, Nazarova A, Carrion-Antoli A, Bonifazi A, Battiti F, Lam J, et al.
Res Sq
. 2024 Jan;
PMID: 38196573
Although aminergic GPCRs are the target for ~25% of approved drugs, developing subtype selective drugs is a major challenge due to the high sequence conservation at their orthosteric binding site....
10.
Boateng C, Nilson A, Placide R, Pham M, Jakobs F, Boldizsar N, et al.
J Med Chem
. 2023 Aug;
66(17):12141-12162.
PMID: 37646374
Pharmacological targeting of the dopamine D receptor (DR)─expressed in brain regions that control cognition, attention, and decision-making─could be useful for several neuropsychiatric disorders including substance use disorders (SUDs). This study...