Alessandra Santillo
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Explore the profile of Alessandra Santillo including associated specialties, affiliations and a list of published articles.
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60
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Recent Articles
1.
Falvo S, Santillo A, Di Fiore M, Venditti M, Grillo G, Latino D, et al.
Cells
. 2024 Aug;
13(16).
PMID: 39195288
D-aspartate (D-Asp) is an amino acid found in high concentrations in the testis and pituitary gland. Increasing evidence suggests that D-Asp promotes spermatogenesis by activating testosterone production in the Leydig...
2.
Falvo S, Grillo G, Latino D, Chieffi Baccari G, Di Fiore M, Venditti M, et al.
Front Cell Dev Biol
. 2024 Aug;
12:1438231.
PMID: 39105170
D-Aspartic Acid (D-Asp) affects spermatogenesis by enhancing the biosynthesis of the sex steroid hormones acting either through the hypothalamus-pituitary-testis axis or directly on Leydig cells. Recently, studies have also demonstrated...
3.
Latino D, Venditti M, Falvo S, Grillo G, Santillo A, Messaoudi I, et al.
Cells
. 2024 Mar;
13(6.
PMID: 38534366
Mitochondria-Associated Endoplasmic Reticulum Membranes (MAMs) mediate the communication between the Endoplasmic Reticulum (ER) and the mitochondria, playing a fundamental role in steroidogenesis. This study aimed to understand how D-aspartate (D-Asp),...
4.
Grillo G, Falvo S, Latino D, Chieffi Baccari G, Venditti M, Di Fiore M, et al.
Ecotoxicol Environ Saf
. 2024 Mar;
274:116202.
PMID: 38479314
Many laboratory studies demonstrated that the exposure to microplastics causes testosterone deficiency and spermatogenic impairment in mammals; however, the mechanism underlying this process remains still unclear. In this study, we...
5.
Falvo S, Minucci S, Santillo A, Senese R, Chieffi Baccari G, Venditti M
Front Endocrinol (Lausanne)
. 2023 Nov;
14:1274035.
PMID: 38027181
Background: Overweight/obesity are metabolic disorder resulting from behavioral, environmental, and heritable causes. WHO estimates that 50% of adults and 30% of children and adolescents are overweight or obese, and, in...
6.
Venditti M, Santillo A, Latino D, Ben Rhouma M, Romano M, Haddadi A, et al.
Ecotoxicol Environ Saf
. 2023 May;
259:115067.
PMID: 37244200
Cadmium (Cd), by producing oxidative stress and acting as an endocrine disruptor, is known to cause severe testicular injury, documented by histological and biomolecular alterations, such as decreased serum testosterone...
7.
Chieffi Baccari G, Iurato G, Santillo A, Dale B
Biomolecules
. 2023 May;
13(5).
PMID: 37238614
In recent decades, male infertility has been correlated with the shortening of sperm telomeres. Telomeres regulate the reproductive lifespan by mediating the synapsis and homologous recombination of chromosomes during gametogenesis....
8.
Santillo A, Falvo S, Venditti M, Di Maio A, Chieffi Baccari G, Errico F, et al.
Biomolecules
. 2023 May;
13(4).
PMID: 37189369
High levels of free D-aspartate (D-Asp) are present in vertebrate testis during post-natal development, coinciding with the onset of testosterone production, which suggests that this atypical amino acid might participate...
9.
Falvo S, Latino D, Santillo A, Chieffi Baccari G, Senese R, Nuzzolillo F, et al.
J Exp Zool A Ecol Integr Physiol
. 2023 Apr;
339(6):535-544.
PMID: 37009779
The epididymis plays an essential role in reproduction, promoting sperm cell maturation. In this study, we investigated the effects of a high-fat diet (HFD) in the three regions of the...
10.
Latino D, Chieffi Baccari G, Di Fiore M, Cioffi F, Venditti M, Giacco A, et al.
Gen Comp Endocrinol
. 2022 Aug;
328:114104.
PMID: 35973585
High-fat diet (HFD) affects the physiology of reproduction in males, and many studies have investigated its detrimental effects. In this study, we investigated the cellular response induced by an HFD...