Alessandra Insinga
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Explore the profile of Alessandra Insinga including associated specialties, affiliations and a list of published articles.
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12
Citations
729
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Recent Articles
1.
Insinga A, Cicalese A, Pelicci P
Blood Cells Mol Dis
. 2014 Feb;
52(4):147-51.
PMID: 24484934
This review discusses the processes of DNA-damage-response and DNA-damage repair in stem and progenitor cells of several tissues. The long life-span of stem cells suggests that they may respond differently...
2.
Insinga A, Cicalese A, Faretta M, Gallo B, Albano L, Ronzoni S, et al.
Proc Natl Acad Sci U S A
. 2013 Feb;
110(10):3931-6.
PMID: 23417300
DNA damage leads to a halt in proliferation owing to apoptosis or senescence, which prevents transmission of DNA alterations. This cellular response depends on the tumor suppressor p53 and functions...
3.
Bonizzi G, Cicalese A, Insinga A, Pelicci P
Trends Mol Med
. 2011 Sep;
18(1):6-12.
PMID: 21907001
Among the hundreds of oncogenes and tumor suppressors that have been identified in the past 50 years, p53 is probably the best characterized; nevertheless, new functions are constantly being discovered....
4.
Colombo N, Parma G, Zanagnolo V, Insinga A
J Clin Oncol
. 2007 Jul;
25(20):2944-51.
PMID: 17617526
Purpose: To describe the clinical management of ovarian stromal cell tumors, which are a heterogeneous group of neoplasms that develop from the sex cords and the ovarian stroma. Design: We...
5.
Carbone R, Botrugno O, Ronzoni S, Insinga A, Di Croce L, Pelicci P, et al.
Mol Cell Biol
. 2006 Feb;
26(4):1288-96.
PMID: 16449642
Leukemia-associated fusion proteins establish aberrant transcriptional programs, which result in the block of hematopoietic differentiation, a prominent feature of the leukemic phenotype. The dissection of the mechanisms of deregulated transcription...
6.
Insinga A, Minucci S, Pelicci P
Cell Cycle
. 2005 May;
4(6):741-3.
PMID: 15908787
Histone deacetylases (HDACs) regulate transcription and specific functions, such as tumor suppression by p53, and are frequently altered in cancer. Inhibitors of HDACs (HDACI) possess anti-tumor activity and are well...
7.
Insinga A, Monestiroli S, Ronzoni S, Gelmetti V, Marchesi F, Viale A, et al.
Nat Med
. 2004 Dec;
11(1):71-6.
PMID: 15619634
Histone deacetylases (HDACs) regulate transcription and specific cellular functions, such as tumor suppression by p53, and are frequently altered in cancer. Inhibitors of HDACs (HDACIs) possess antitumor activity and are...
8.
Insinga A, Pelicci P, Inucci S
Cell Cycle
. 2004 Dec;
4(1):67-9.
PMID: 15611639
Leukemic cells are defined by two main biological features: arrest of differentiation at a specific stage compatible with continued proliferation, and enhanced resistance to stress. Recent work shows that the...
9.
Insinga A, Monestiroli S, Ronzoni S, Carbone R, Pearson M, Pruneri G, et al.
EMBO J
. 2004 Feb;
23(5):1144-54.
PMID: 14976551
Mutations of p53 are remarkably rare in acute promyelocytic leukemias (APLs). Here, we demonstrate that the APL-associated fusion proteins PML-RAR and PLZF-RAR directly inhibit p53, allowing leukemic blasts to evade...
10.
Cordenonsi M, Dupont S, Maretto S, Insinga A, Imbriano C, Piccolo S
Cell
. 2003 May;
113(3):301-14.
PMID: 12732139
The p53 tumor suppressor belongs to a family of proteins that sense multiple cellular inputs to regulate cell proliferation, apoptosis, and differentiation. Whether and how these functions of p53 intersect...