Alessandra Gentilini
Overview
Explore the profile of Alessandra Gentilini including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
371
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Recent Articles
1.
Porro N, Spinola-Lasso E, Pastore M, Caligiuri A, Di Tommaso L, Marra F, et al.
Cancers (Basel)
. 2025 Jan;
16(24.
PMID: 39766138
Among solid tumors, cholangiocarcinoma (CCA) emerges as one of the most difficult to eradicate. The silent and asymptomatic nature of this tumor, particularly in its early stages, as well as...
2.
Caligiuri A, Becatti M, Porro N, Borghi S, Marra F, Pastore M, et al.
Antioxidants (Basel)
. 2024 Jan;
13(1).
PMID: 38247453
Cholangiocarcinoma (CCA) is a primary liver tumor that accounts for 2% of all cancer-related deaths worldwide yearly. It can arise from cholangiocytes of biliary tracts, peribiliary glands, and possibly from...
3.
Caligiuri A, Gitto S, Lori G, Marra F, Parola M, Cannito S, et al.
Cancers (Basel)
. 2022 Sep;
14(17).
PMID: 36077744
Primary liver cancers represent the third-most-common cause of cancer-related mortality worldwide, with an incidence of 80-90% for hepatocellular carcinoma (HCC) and 10-15% for cholangiocarcinoma (CCA), and an increasing morbidity and...
4.
Caligiuri A, Gentilini A, Pastore M, Gitto S, Marra F
Cells
. 2021 Oct;
10(10).
PMID: 34685739
Chronic liver injury of different etiologies may result in hepatic fibrosis, a scar formation process consisting in altered deposition of extracellular matrix. Progression of fibrosis can lead to impaired liver...
5.
Gentilini A, Lori G, Caligiuri A, Raggi C, Maira G, Pastore M, et al.
Hepatology
. 2021 May;
74(4):2007-2020.
PMID: 33959996
Background And Aims: Cholangiocarcinoma (CCA) is characterized by high resistance to chemotherapy and poor prognosis. Several oncogenic pathways converge on activation of extracellular signal-regulated kinase 5 (ERK5), whose role in...
6.
Caligiuri A, Pastore M, Lori G, Raggi C, Maira G, Marra F, et al.
Cancers (Basel)
. 2020 Aug;
12(8).
PMID: 32784743
Cholangiocarcinoma (CCA), a heterogeneous tumor with poor prognosis, can arise at any level in the biliary tree. It may derive from epithelial cells in the biliary tracts and peribiliary glands...
7.
Pastore M, Lori G, Gentilini A, Taddei M, Maira G, Campani C, et al.
Cells
. 2020 Mar;
9(3).
PMID: 32138158
Cholangiocarcinoma (CCA) is a deadly tumor without an effective therapy. Unique metabolic and bioenergetics features are important hallmarks of tumor cells. Metabolic plasticity allows cancer cells to survive in poor...
8.
Maira G, Gentilini A, Pastore M, Caligiuri A, Piombanti B, Raggi C, et al.
Oncogenesis
. 2019 Oct;
8(11):61.
PMID: 31641101
Cholangiocarcinoma (CCA) is a particularly aggressive hepatobiliary malignancy, for which the molecular mechanisms underlying the malignant phenotype are still poorly understood, and novel and effective therapeutic strategies are limited. The...
9.
Gentilini A, Caligiuri A, Raggi C, Rombouts K, Pinzani M, Lori G, et al.
Biochim Biophys Acta Mol Basis Dis
. 2019 May;
1865(9):2246-2256.
PMID: 31059778
Development of cholangiocarcinoma (CCA) is dependent on a cross-talk with stromal cells, which release different chemokines including CXCL12, that interacts with two different receptors, CXCR4 and CXCR7. The aim of...
10.
Gentilini A, Pastore M, Marra F, Raggi C
Int J Mol Sci
. 2018 Sep;
19(10).
PMID: 30249019
Cholangiocarcinoma (CCA) is a severe and mostly intractable adenocarcinoma of biliary epithelial cells. A typical feature of CCA is its highly desmoplastic microenvironment containing fibrogenic connective tissue and an abundance...