Alessandra Castaldi
Overview
Explore the profile of Alessandra Castaldi including associated specialties, affiliations and a list of published articles.
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16
Citations
287
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Recent Articles
1.
St Pierre L, Berhan A, Sung E, Alvarez J, Wang H, Ji Y, et al.
Biochim Biophys Acta Mol Basis Dis
. 2024 Nov;
1871(3):167572.
PMID: 39547519
Idiopathic pulmonary fibrosis (IPF) is a lethal progressive lung disease urgently needing new therapies. Current treatments only delay disease progression, leaving lung transplant as the sole remaining option. Recent studies...
2.
Yang M, Shen H, Flodby P, Koss M, Bassiouni R, Liu Y, et al.
Cell Rep
. 2023 Nov;
42(12):113286.
PMID: 37995179
Lung adenocarcinoma (LUAD) is the most prevalent subtype of lung cancer and presents clinically with a high degree of biological heterogeneity and distinct clinical outcomes. The current paradigm of LUAD...
3.
Shen H, Chen W, Liu Y, Castaldi A, Castillo J, Horie M, et al.
bioRxiv
. 2023 Oct;
PMID: 37905051
Alveolar epithelial regeneration is critical for normal lung function and becomes dysregulated in disease. While alveolar type 2 (AT2) and club cells are known distal lung epithelial progenitors, determining if...
4.
Rice J, Weekley B, Kanholm T, Chen Z, Lee S, Fernandez D, et al.
Epigenetics Chromatin
. 2021 May;
14(1):23.
PMID: 34001241
Background: Selective proteolysis of the histone H3 N-terminal tail (H3NT) is frequently observed during eukaryotic development, generating a cleaved histone H3 (H3cl) product within a small, but significant, portion of...
5.
Horie M, Castaldi A, Sunohara M, Wang H, Ji Y, Liu Y, et al.
Cells
. 2020 Nov;
9(11).
PMID: 33187367
Molecular and functional characterization of alveolar epithelial type I (AT1) cells has been challenging due to difficulty in isolating sufficient numbers of viable cells. Here we performed single-cell RNA-sequencing (scRNA-seq)...
6.
Tian L, Gao J, Garcia I, Chen H, Castaldi A, Chen Y
Wiley Interdiscip Rev Dev Biol
. 2020 Nov;
10(6):e399.
PMID: 33145915
The pulmonary system is comprised of two main compartments, airways and alveolar space. Their tissue and cellular complexity ensure lung function and protection from external agents, for example, virus. Two-dimensional...
7.
Climent M, Viggiani G, Chen Y, Coulis G, Castaldi A
Int J Mol Sci
. 2020 Jun;
21(12).
PMID: 32575472
Reactive oxygen species (ROS) affect many cellular functions and the proper redox balance between ROS and antioxidants contributes substantially to the physiological welfare of the cell. During pathological conditions, an...
8.
Castaldi A, Horie M, Rieger M, Dubourd M, Sunohara M, Pandit K, et al.
Am J Physiol Lung Cell Mol Physiol
. 2020 May;
319(1):L173-L184.
PMID: 32432919
The alveolar epithelium is comprised of two cell types, alveolar epithelial type 1 (AT1) and type 2 (AT2) cells, the latter being capable of self-renewal and transdifferentiation into AT1 cells...
9.
Hor P, Punj V, Calvert B, Castaldi A, Miller A, Carraro G, et al.
iScience
. 2020 May;
23(5):101083.
PMID: 32380423
Expansion of pulmonary neuroendocrine cells (PNECs) is a pathological feature of many human lung diseases. Human PNECs are inherently difficult to study due to their rarity (<1% of total lung...
10.
Luo J, Chimge N, Zhou B, Flodby P, Castaldi A, Firth A, et al.
Int J Cancer
. 2018 Oct;
143(12):3169-3180.
PMID: 30325015
Claudins are a family of transmembrane proteins integral to the structure and function of tight junctions (TJ). Disruption of TJ and alterations in claudin expression are important features of invasive...