Ales Holoubek
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Explore the profile of Ales Holoubek including associated specialties, affiliations and a list of published articles.
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26
Citations
158
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Recent Articles
1.
Maly P, Strachotova D, Holoubek A, Herman P
Nat Commun
. 2024 Sep;
15(1):8019.
PMID: 39271727
Fluorescence lifetime imaging microscopy (FLIM) is a well-established technique with numerous imaging applications. Yet, one of the limitations of FLIM is that it only provides information about the emitting state....
2.
Dvoracek L, Markova J, Holoubek A, Grebenova D, Kundrat D, Kuzelova K, et al.
Ann Hematol
. 2023 Aug;
102(10):2725-2734.
PMID: 37639050
Somatic JAK2 mutations are the main molecular cause of the vast majority of polycythemia vera (PV) cases. According to a recent structural model, the prevalent acquired V617F mutation improves the...
3.
Trsova I, Hrustincova A, Krejcik Z, Kundrat D, Holoubek A, Staflova K, et al.
Mol Oncol
. 2023 Jul;
17(12):2565-2583.
PMID: 37408496
Mutations in the splicing factor 3b subunit 1 (SF3B1) gene are frequent in myelodysplastic neoplasms (MDS). Because the splicing process is involved in the production of circular RNAs (circRNAs), we...
4.
Wolfova K, Otevrelova P, Holoubek A, Brodska B
Biochim Biophys Acta Mol Cell Res
. 2023 Jun;
1870(7):119501.
PMID: 37276927
Reactivating p53 and Inducing Tumor Apoptosis (RITA) has been reported to increase the p53 activity and to trigger p53-dependent apoptosis in cancer cells with wild-type p53. Tumor suppressor p53 interacts...
5.
Strachotova D, Holoubek A, Brodska B, Herman P
Methods Appl Fluoresc
. 2023 Jun;
11(3).
PMID: 37267995
Enhanced green fluorescence protein (EGFP) is a fluorescent tag commonly used in cellular and biomedical applications. Surprisingly, some interesting photochemical properties of EGFP have remained unexplored. Here we report on...
6.
Strachotova D, Holoubek A, Wolfova K, Brodska B, Herman P
FEBS J
. 2023 Apr;
290(17):4281-4299.
PMID: 37119456
Specific C-terminal nucleophosmin (NPM) mutations are related to the acute myeloid leukaemia and cause mistargeting of mutated NPM (NPMmut) to the cytoplasm. Consequently, multiple NPM-interacting partners, e.g., the tumour suppressor...
7.
Holoubek A, Strachotova D, Otevrelova P, Roselova P, Herman P, Brodska B
Cancers (Basel)
. 2021 Jul;
13(13).
PMID: 34209894
Nucleophosmin (NPM) interaction with tumor suppressor p53 is a part of a complex interaction network and considerably affects cellular stress response. The impact of mutations on its interaction with p53...
8.
Antonarakis S, Holoubek A, Rapti M, Rademaker J, Meylan J, Iwaszkiewicz J, et al.
Hum Mol Genet
. 2021 Mar;
31(1):1-9.
PMID: 33693784
Knobloch syndrome is an autosomal recessive phenotype mainly characterized by retinal detachment and encephalocele caused by biallelic pathogenic variants in the COL18A1 gene. However, there are patients clinically diagnosed as...
9.
Kuzelova K, Obr A, Roselova P, Grebenova D, Otevrelova P, Brodska B, et al.
Cell Adh Migr
. 2021 Jan;
15(1):18-36.
PMID: 33464167
P21-activated kinases (PAK) regulate processes associated with cytoskeleton dynamics. PAK expression in leukemia cells was measured on protein and mRNA levels. In functional assays, we analyzed the effect of PAK...
10.
Sasinkova M, Herman P, Holoubek A, Strachotova D, Otevrelova P, Grebenova D, et al.
Sci Rep
. 2021 Jan;
11(1):1084.
PMID: 33441774
Nucleophosmin (NPM) mutations causing its export from the nucleoli to the cytoplasm are frequent in acute myeloid leukemia (AML). Due to heterooligomerization of wild type NPM with the AML-related mutant,...