Alena V Makarova
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Explore the profile of Alena V Makarova including associated specialties, affiliations and a list of published articles.
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39
Citations
488
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Recent Articles
1.
Shilkin E, Petrova D, Kruchinin A, Zharkov D, Makarova A
DNA Repair (Amst)
. 2025 Mar;
148:103815.
PMID: 40031118
Сytosine methylation in CpG dinucleotides is the most common epigenetic mark in human cells. Under active demethylation process 5-methylcytosine (mC) can be converted to 5-hydroxymethylcytosine (hmC). Cytosine methylation increases the...
2.
Yudkina A, Novikova A, Stolyarenko A, Makarova A, Zharkov D
Int J Mol Sci
. 2025 Jan;
26(2).
PMID: 39859356
The apurinic/apyrimidinic site (AP site) is a highly mutagenic and cytotoxic DNA lesion. Normally, AP sites are removed from DNA by base excision repair (BER). Methoxyamine (MOX), a BER inhibitor...
3.
Boldinova E, Baranovskiy A, Esyunina D, Tahirov T, Makarova A
DNA Repair (Amst)
. 2024 Aug;
142:103741.
PMID: 39153403
PrimPol is a human DNA primase involved in DNA damage tolerance pathways by restarting DNA replication downstream of DNA lesions and non-canonical DNA structures. Activity and affinity to DNA relays...
4.
Shilkin E, Petrova D, Novikova A, Boldinova E, Zharkov D, Makarova A
DNA Repair (Amst)
. 2024 Jul;
141:103712.
PMID: 38959714
Epigenetic cytosine methylation covers most of genomic CpG dinucleotides in human cells. In addition to common deamination-mediated mutagenesis at CpG sites, an alternative deamination-independent pathway associated with DNA polymerase activity...
5.
Stolyarenko A, Novikova A, Shilkin E, Poltorachenko V, Makarova A
Int J Mol Sci
. 2024 Apr;
25(7).
PMID: 38612916
Eukaryotic REV1 serves as a scaffold protein for the coordination of DNA polymerases during DNA translesion synthesis. Besides this structural role, REV1 is a Y-family DNA polymerase with its own...
6.
Boldinova E, Baranovskiy A, Filina Y, Miftakhova R, Shamsutdinova Y, Tahirov T, et al.
J Mol Biol
. 2024 Mar;
436(9):168542.
PMID: 38492718
PrimPol is a human DNA primase-polymerase which restarts DNA synthesis beyond DNA lesions and non-B DNA structures blocking replication. Disfunction of PrimPol in cells leads to slowing of DNA replication...
7.
Kruchinin A, Kamzeeva P, Zharkov D, Aralov A, Makarova A
Int J Mol Sci
. 2024 Jan;
25(2).
PMID: 38279342
Numerous studies have shown that oxidative modifications of guanine (7,8-dihydro-8-oxoguanine, 8-oxoG) can affect cellular functions. 7,8-Dihydro-8-oxoadenine (8-oxoA) is another abundant paradigmatic ambiguous nucleobase but findings reported on the mutagenicity of...
8.
Gromova A, Boldinova E, Kim D, Chuprov-Netochin R, Leonov S, Pustovalova M, et al.
Biochemistry (Mosc)
. 2023 Dec;
88(11):1933-1943.
PMID: 38105210
Human DNA primase/polymerase PrimPol synthesizes DNA primers de novo after replication fork stalling at the sites of DNA damage, thus contributing to the DNA damage tolerance. The role of PrimPol...
9.
Boldinova E, Makarova A
Biochemistry (Mosc)
. 2023 Sep;
88(8):1139-1155.
PMID: 37758313
Transmission of genetic information depends on successful completion of DNA replication. Genomic DNA is subjected to damage on a daily basis. DNA lesions create obstacles for DNA polymerases and can...
10.
Yudkina A, Barmatov A, Bulgakov N, Boldinova E, Shilkin E, Makarova A, et al.
Int J Mol Sci
. 2023 Jul;
24(13).
PMID: 37446048
DNA-protein cross-links remain the least-studied type of DNA damage. Recently, their repair was shown to involve proteolysis; however, the fate of the peptide remnant attached to DNA is unclear. Particularly,...