Aleksandra Leligdowicz
Overview
Explore the profile of Aleksandra Leligdowicz including associated specialties, affiliations and a list of published articles.
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1697
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Recent Articles
1.
McChesney C, Orozco N, Fiorini K, Wong M, Slessarev M, Prager R, et al.
Crit Care Med
. 2025 Feb;
PMID: 40009025
Objectives: To determine the impact of short-acting beta-blocker therapy on outcomes in adult patients with septic shock. Data Sources: We searched MEDLINE, Embase, and unpublished sources from inception to April...
2.
Leligdowicz A, Wiersinga W
Am J Respir Crit Care Med
. 2025 Jan;
211(3):307-309.
PMID: 39847719
No abstract available.
3.
Valda Toro P, Willmore A, Wu N, Delucchi K, Jauregui A, Sinha P, et al.
Crit Care
. 2024 Apr;
28(1):132.
PMID: 38649920
Background: Rapidly improving acute respiratory distress syndrome (RIARDS) is an increasingly appreciated subgroup of ARDS in which hypoxemia improves within 24 h after initiation of mechanical ventilation. Detailed clinical and...
4.
Leligdowicz A, Harhay M, Calfee C
NEJM Evid
. 2024 Feb;
1(11):EVIDra2200118.
PMID: 38319856
Immune Modulation in Sepsis, ARDS, and Covid-19Leligdowicz et al. consider the history and future of immunomodulating therapies in sepsis and ARDS, including ARDS due to Covid-19, and remark on the...
5.
Tschirhart B, Lu X, Mokale Kognou A, Martin C, Slessarev M, Fraser D, et al.
Front Pharmacol
. 2024 Jan;
14:1299613.
PMID: 38269269
Annexin A5 is a phosphatidylserine binding protein with anti-inflammatory, anticoagulant and anti-apoptotic properties. Preclinical studies have shown that annexin A5 inhibits pro-inflammatory responses and improves organ function and survival in...
6.
Neyton L, Sinha P, Sarma A, Mick E, Kalantar K, Chen S, et al.
Am J Respir Crit Care Med
. 2024 Jan;
209(7):805-815.
PMID: 38190719
Two molecular phenotypes of sepsis and acute respiratory distress syndrome, termed hyperinflammatory and hypoinflammatory, have been consistently identified by latent class analysis in numerous cohorts, with widely divergent clinical outcomes...
7.
8.
Martin C, Slessarev M, Campbell E, Basmaji J, Ball I, Fraser D, et al.
Crit Care Explor
. 2023 Oct;
5(10):e0986.
PMID: 37811130
Objectives: To evaluate the study design and feasibility of drug administration and safety in a randomized clinical trial of recombinant human annexin A5 (SY-005), a constitutively expressed protein with anti-inflammatory,...
9.
Van Singer M, Brahier T, Koch J, Hugli P, Weckman A, Zhong K, et al.
BMC Infect Dis
. 2023 Sep;
23(1):630.
PMID: 37752433
Background: A prospective observational cohort study of COVID-19 patients in a single Emergency Department (ED) showed that sTREM-1- and IL-6-based algorithms were highly predictive of adverse outcome (Van Singer et...
10.
Sinha P, Kerchberger V, Willmore A, Chambers J, Zhuo H, Abbott J, et al.
Lancet Respir Med
. 2023 Aug;
11(11):965-974.
PMID: 37633303
Background: In sepsis and acute respiratory distress syndrome (ARDS), heterogeneity has contributed to difficulty identifying effective pharmacotherapies. In ARDS, two molecular phenotypes (hypoinflammatory and hyperinflammatory) have consistently been identified, with...