Aleksandr Morgulis
Overview
Explore the profile of Aleksandr Morgulis including associated specialties, affiliations and a list of published articles.
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7
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1521
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Recent Articles
1.
Mario-Vasquez J, Bagal U, Lowe E, Morgulis A, Phan J, Sexton D, et al.
PLoS One
. 2024 Jan;
19(1):e0291406.
PMID: 38241320
Candida auris is a newly emerged multidrug-resistant fungus capable of causing invasive infections with high mortality. Despite intense efforts to understand how this pathogen rapidly emerged and spread worldwide, its...
2.
Morgulis A, Agarwala R
Gigascience
. 2020 Apr;
9(4).
PMID: 32315028
Background: Alignment of sequence reads generated by next-generation sequencing is an integral part of most pipelines analyzing next-generation sequencing data. A number of tools designed to quickly align a large...
3.
Steinberg K, Schneider V, Graves-Lindsay T, Fulton R, Agarwala R, Huddleston J, et al.
Genome Res
. 2014 Nov;
24(12):2066-76.
PMID: 25373144
A complete reference assembly is essential for accurately interpreting individual genomes and associating variation with phenotypes. While the current human reference genome sequence is of very high quality, gaps and...
4.
Morgulis A, Coulouris G, Raytselis Y, Madden T, Agarwala R, Schaffer A
Bioinformatics
. 2008 Jun;
24(16):1757-64.
PMID: 18567917
Motivation: The BLAST software package for sequence comparison speeds up homology search by preprocessing a query sequence into a lookup table. Numerous research studies have suggested that preprocessing the database...
5.
Morgulis A, Gertz E, Schaffer A, Agarwala R
J Comput Biol
. 2006 Jun;
13(5):1028-40.
PMID: 16796549
The DUST module has been used within BLAST for many years to mask low-complexity sequences. In this paper, we present a new implementation of the DUST module that uses the...
6.
Morgulis A, Gertz E, Schaffer A, Agarwala R
Bioinformatics
. 2005 Nov;
22(2):134-41.
PMID: 16287941
Motivation: Matches to repetitive sequences are usually undesirable in the output of DNA database searches. Repetitive sequences need not be matched to a query, if they can be masked in...
7.
Altschul S, Wootton J, Gertz E, Agarwala R, Morgulis A, Schaffer A, et al.
FEBS J
. 2005 Oct;
272(20):5101-9.
PMID: 16218944
Almost all protein database search methods use amino acid substitution matrices for scoring, optimizing, and assessing the statistical significance of sequence alignments. Much care and effort has therefore gone into...