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Aleksander Rust

Explore the profile of Aleksander Rust including associated specialties, affiliations and a list of published articles. Areas
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Articles 8
Citations 84
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Recent Articles
1.
Lamb D, Rust A, Rudisch A, Gluxam T, Harrer N, Machat H, et al.
Oncotarget . 2020 Apr; 11(14):1257-1272. PMID: 32292575
SYK has been reported to possess both tumour promotor and repressor activities and deletion has been linked to a pro-proliferative / pro-invasive phenotype in breast tumours. It is unclear whether...
2.
Rust A, Shah S, Hautbergue G, Davletov B
Toxins (Basel) . 2018 Jun; 10(7). PMID: 29954071
Immunotoxins are being investigated as anti-cancer therapies and consist of a cytotoxic enzyme fused to a cancer targeting antibody. All currently used toxins function via the inhibition of protein synthesis,...
3.
Lombardi B, Ashford P, Moya-Garcia A, Rust A, Crawford M, Williams S, et al.
Oncotarget . 2017 Dec; 8(61):102898-102911. PMID: 29262532
The FGFR3-TACC3 fusion is an oncogenic driver in diverse malignancies, including bladder cancer, characterized by upregulated tyrosine kinase activity. To gain insights into distinct properties of FGFR3-TACC3 down-stream signalling, we...
4.
Rust A, Doran C, Hart R, Binz T, Stickings P, Sesardic D, et al.
Front Pharmacol . 2017 Nov; 8:796. PMID: 29170639
Botulinum neurotoxins (BoNTs) type A and type B are commonly used as biopharmaceutics for neurological diseases, uniquely allowing months-long paralysis of target muscles. Their exquisite neuronal specificity is conferred by...
5.
Rust A, Partridge L, Davletov B, Hautbergue G
Toxins (Basel) . 2017 Oct; 9(11). PMID: 29076988
Ribosome inactivating proteins (RIPs) form a class of toxins that was identified over a century ago. They continue to fascinate scientists and the public due to their very high activity...
6.
Rust A, Leese C, Binz T, Davletov B
Oncotarget . 2016 Apr; 7(22):33220-8. PMID: 27121208
Neuroblastomas constitute a major cause of cancer-related deaths in young children. In recent years, a number of translation-inhibiting enzymes have been evaluated for killing neuroblastoma cells. Here we investigated the...
7.
Rust A, Hassan H, Sedelnikova S, Niranjan D, Hautbergue G, Abbas S, et al.
Sci Rep . 2015 Jul; 5:12444. PMID: 26207613
Intracellular delivery of biologically active proteins remains a formidable challenge in biomedical research. Here we show that biomedically relevant enzymes can be delivered into cells using a new DNA transfection...
8.
Arsenault J, Cuijpers S, Ferrari E, Niranjan D, Rust A, Leese C, et al.
J Neurochem . 2013 Dec; 129(5):781-91. PMID: 24372287
Soluble N-ethylmaleimide sensitive factor attachment protein receptors (SNAREs) are crucial for exocytosis, trafficking, and neurite outgrowth, where vesicular SNAREs are directed toward their partner target SNAREs: synaptosomal-associated protein of 25...