Alejandro Valenzuela
Overview
Explore the profile of Alejandro Valenzuela including associated specialties, affiliations and a list of published articles.
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11
Citations
201
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Recent Articles
1.
Schmid T, Elie J, Redlich R, Shvareva V, Rakuljic A, Ji M, et al.
Science
. 2024 Feb;
383(6690):eabn3263.
PMID: 38422184
Vocal production learning ("vocal learning") is a convergently evolved trait in vertebrates. To identify brain genomic elements associated with mammalian vocal learning, we integrated genomic, anatomical, and neurophysiological data from...
2.
Baker K, Miller H, Doherty S, Gray H, Daujat J, Cakirlar C, et al.
Proc Natl Acad Sci U S A
. 2024 Feb;
121(8):e2310051121.
PMID: 38346198
Over the last 10,000 y, humans have manipulated fallow deer populations with varying outcomes. Persian fallow deer () are now endangered. European fallow deer () are globally widespread and are...
3.
Kuderna L, Ulirsch J, Rashid S, Ameen M, Sundaram L, Hickey G, et al.
Nature
. 2023 Nov;
625(7996):735-742.
PMID: 38030727
Noncoding DNA is central to our understanding of human gene regulation and complex diseases, and measuring the evolutionary sequence constraint can establish the functional relevance of putative regulatory elements in...
4.
Barteri F, Valenzuela A, Farre X, de Juan D, Muntane G, Esteve-Altava B, et al.
Bioinformatics
. 2023 Oct;
39(10).
PMID: 37846039
Motivation: Coincidence of Convergent Amino Acid Substitutions (CAAS) with phenotypic convergences allow pinpointing genes and even individual mutations that are likely to be associated with trait variation within their phylogenetic...
5.
Kuderna L, Gao H, Janiak M, Kuhlwilm M, Orkin J, Bataillon T, et al.
Science
. 2023 Jun;
380(6648):906-913.
PMID: 37262161
The rich diversity of morphology and behavior displayed across primate species provides an informative context in which to study the impact of genomic diversity on fundamental biological processes. Analysis of...
6.
Gao H, Hamp T, Ede J, Schraiber J, McRae J, Singer-Berk M, et al.
Science
. 2023 Jun;
380(6648):eabn8153.
PMID: 37262156
Personalized genome sequencing has revealed millions of genetic differences between individuals, but our understanding of their clinical relevance remains largely incomplete. To systematically decipher the effects of human genetic variants,...
7.
Gao H, Hamp T, Ede J, Schraiber J, McRae J, Singer-Berk M, et al.
bioRxiv
. 2023 May;
PMID: 37205491
One Sentence Summary: Deep learning classifier trained on 4.3 million common primate missense variants predicts variant pathogenicity in humans.
8.
Christmas M, Kaplow I, Genereux D, Dong M, Hughes G, Li X, et al.
Science
. 2023 Apr;
380(6643):eabn3943.
PMID: 37104599
Zoonomia is the largest comparative genomics resource for mammals produced to date. By aligning genomes for 240 species, we identify bases that, when mutated, are likely to affect fitness and...
9.
Melin A, Orkin J, Janiak M, Valenzuela A, Kuderna L, Marrone 3rd F, et al.
Am J Primatol
. 2021 Apr;
83(6):e23255.
PMID: 33792947
The novel coronavirus SARS-CoV-2, which in humans leads to the disease COVID-19, has caused global disruption and more than 2 million fatalities since it first emerged in late 2019. As...
10.
Melin A, Orkin J, Janiak M, Valenzuela A, Kuderna L, Marrone 3rd F, et al.
bioRxiv
. 2021 Feb;
PMID: 33564767
The novel coronavirus SARS-CoV-2, which in humans leads to the disease COVID-19, has caused global disruption and more than 1.5 million fatalities since it first emerged in late 2019. As...