Alejandro Dorenbaum
Overview
Explore the profile of Alejandro Dorenbaum including associated specialties, affiliations and a list of published articles.
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21
Citations
548
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Recent Articles
1.
Karaa A, Johnson N, Clarkson I, Newman W, Dorenbaum A, Cohen B
Neurol Clin Pract
. 2024 Jan;
14(1):e200229.
PMID: 38229875
Background And Objectives: Primary mitochondrial myopathies are genetic disorders that primarily affect peripheral skeletal muscles. Patients with primary mitochondrial myopathies often experience muscle weakness, fatigue, and other significant impacts on...
2.
Bowlus C, Eksteen B, Cheung A, Thorburn D, Moylan C, Pockros P, et al.
Hepatol Commun
. 2023 May;
7(6).
PMID: 37184523
Background: Primary sclerosing cholangitis (PSC) is frequently associated with pruritus, which significantly impairs quality of life. Maralixibat is a selective ileal bile acid transporter (IBAT) inhibitor that lowers circulating bile...
3.
DAnnibale O, Phua Y, Vant Land C, Karunanidhi A, Dorenbaum A, Mohsen A, et al.
Cells
. 2022 Sep;
11(17).
PMID: 36078043
Very long-chain acyl-CoA dehydrogenase (VLCAD) deficiency is an autosomal recessive disease that prevents the body from utilizing long-chain fatty acids for energy, most needed during stress and fasting. Symptoms can...
4.
Loomes K, Squires R, Kelly D, Rajwal S, Soufi N, Lachaux A, et al.
Hepatol Commun
. 2022 May;
6(9):2379-2390.
PMID: 35507739
Children with progressive familial intrahepatic cholestasis, including bile salt export pump (BSEP) and familial intrahepatic cholestasis-associated protein 1 (FIC1) deficiencies, suffer debilitating cholestatic pruritus that adversely affects growth and quality...
5.
Gonzales E, Hardikar W, Stormon M, Baker A, Hierro L, Gliwicz D, et al.
Lancet
. 2021 Nov;
398(10311):1581-1592.
PMID: 34755627
Background: Alagille syndrome is a rare genetic disease that often presents with severe cholestasis and pruritus. There are no approved drugs for management. Maralixibat, an apical, sodium-dependent, bile acid transport...
6.
Mayo M, Pockros P, Jones D, Bowlus C, Levy C, Patanwala I, et al.
Hepatol Commun
. 2019 Mar;
3(3):365-381.
PMID: 30859149
Primary biliary cholangitis (PBC) is typically associated with elevated serum bile acid levels and pruritus, but pruritus is often refractory to treatment with existing therapies. This phase 2 study assessed...
7.
Tiessen R, Kennedy C, Keller B, Levin N, Acevedo L, Gedulin B, et al.
BMC Gastroenterol
. 2018 Jan;
18(1):3.
PMID: 29304731
Background: Pathogenesis in non-alcoholic steatohepatitis (NASH) involves abnormal cholesterol metabolism and hepatic accumulation of toxic free cholesterol. Apical sodium-dependent bile acid transporter (ASBT) inhibition in the terminal ileum may facilitate...
8.
Kamath B, Abetz-Webb L, Kennedy C, Hepburn B, Gauthier M, Johnson N, et al.
Patient
. 2017 Jul;
11(1):69-82.
PMID: 28710680
Objectives: The aim was to develop a clinical outcome assessment (COA) for itching in children with cholestatic pruritus. Methods: This prospective study aimed to enroll patients aged 4-30 years with...
9.
Luskin A, Chipps B, Rasouliyan L, Miller D, Haselkorn T, Dorenbaum A
J Allergy Clin Immunol Pract
. 2014 Sep;
2(5):544-52.e1-2.
PMID: 25213047
Background: Few data are available that evaluate the relationship among asthma exacerbations, asthma triggers, and asthma-related quality of life (QoL). Objective: To evaluate the impact of asthma exacerbations and asthma...
10.
Longo N, Harding C, Burton B, Grange D, Vockley J, Wasserstein M, et al.
Lancet
. 2014 Apr;
384(9937):37-44.
PMID: 24743000
Background: Phenylketonuria is an inherited disease caused by impaired activity of phenylalanine hydroxylase, the enzyme that converts phenylalanine to tyrosine, leading to accumulation of phenylalanine and subsequent neurocognitive dysfunction. Phenylalanine...