Alejandro Blanco-Labra
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Explore the profile of Alejandro Blanco-Labra including associated specialties, affiliations and a list of published articles.
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30
Citations
207
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Recent Articles
1.
Diaz-Betancourt A, Galicia-Castillo M, Morales-Tlalpan V, Chavez-Servin J, Blanco-Labra A, Garcia-Gasca T, et al.
Int J Mol Sci
. 2025 Feb;
26(3).
PMID: 39940827
Lectins are proteins that specifically recognize carbohydrates on cell membranes, triggering several cellular events such as apoptosis of cancer-transformed cells; however, the mechanisms of action remain incompletely understood. Our research...
2.
Martinez-Alarcon D, Castro-Guillen J, Fitches E, Gatehouse J, Przyborski S, Moreno-Celis U, et al.
Int J Mol Sci
. 2025 Jan;
25(24.
PMID: 39769023
Recently, we reported that a recombinant Tepary bean () lectin (rTBL-1) induces apoptosis in colon cancer cell lines and that cytotoxicity was related to differential recognition of β1-6 branched -glycans....
3.
Dena-Beltran J, Nava-Dominguez P, Palmerin-Carreno D, Martinez-Alarcon D, Moreno-Celis U, Valle-Pacheco M, et al.
Pharmaceuticals (Basel)
. 2023 Jun;
16(2).
PMID: 37259433
Previous works showed that a Tepary bean lectin fraction (TBLF) induced apoptosis on colon cancer cells and inhibited early colonic tumorigenesis. One Tepary bean (TB) lectin was expressed in (rTBL-1),...
4.
Torres-Arteaga I, Blanco-Labra A, Mendiola-Olaya E, Garcia-Gasca T, Aguirre-Mancilla C, Ortega-de-Santiago A, et al.
Glycoconj J
. 2022 Nov;
40(1):69-84.
PMID: 36385669
We present the purification and characterization of the two most abundant isoforms of lectins isolated from Tepary bean (Phaseolus acutifolius) seeds, which have been shown to differentially affect the survival...
5.
Roldan-Padron O, Cruz-Perez M, Castro-Guillen J, Garcia-Arredondo J, Mendiola-Olaya E, Saldana-Gutierrez C, et al.
Biology (Basel)
. 2022 May;
11(5).
PMID: 35625389
Hybridization is defined as the interbreeding of individuals from two populations distinguishable by one or more heritable characteristics. Snake hybridization represents an interesting opportunity to analyze variability and how genetics...
6.
Martinez-Alarcon D, Mora-Aviles A, Espinoza-Nunez A, Serrano Jamaica L, Cruz-Hernandez A, Rodriguez-Torres A, et al.
J Biotechnol
. 2021 Jun;
306S:100013.
PMID: 34112377
Tepary bean (Phaseolus acutifolius) lectin fraction (TBLF) has been shown to specifically bind and induce cell death of different types of cancer cells and also has exhibited an effect on...
7.
Vega-Rojas L, Luzardo-Ocampo I, Mosqueda J, Palmerin-Carreno D, Escobedo-Reyes A, Blanco-Labra A, et al.
Int J Mol Sci
. 2021 Jan;
22(3).
PMID: 33494324
Tepary bean () lectins exhibit differential and biological effects, but their gastrointestinal interactions and digestion have not yet been assessed. This work aimed to evaluate the changes of a recombinant...
8.
Pita-Lopez W, Gomez-Garay M, Blanco-Labra A, Aguilera-Barreyro A, Reis-de Souza T, Olvera-Ramirez A, et al.
Toxicol Res (Camb)
. 2020 Nov;
9(5):714-725.
PMID: 33178432
The Tepary bean () lectin fraction (TBLF) exhibits differential cytotoxicity on colon cancer cells and inhibition of early tumorigenesis in the colon (50 mg/kg, three times per week, for 6 ...
9.
Castellanos-Arevalo A, Estrada-Luna A, Cabrera-Ponce J, Valencia-Lozano E, Herrera-Ubaldo H, de Folter S, et al.
Plant Cell Rep
. 2020 May;
39(9):1143-1160.
PMID: 32430681
Transgenic A. hypochondriacus and A. hybridus roots were generated. Further, a distinct plant regeneration program via somatic embryos produced from hairy roots was established. Work was implemented to develop an...
10.
Martinez-Alarcon D, Varrot A, Fitches E, Gatehouse J, Cao M, Pyati P, et al.
Biomolecules
. 2020 Apr;
10(4).
PMID: 32340396
Herein, we report the production of a recombinant Tepary bean lectin (TBL-1), its three-dimensional (3D) structure, and its differential recognition for cancer-type glycoconjugates. TBL-1 was expressed in yielding 316 mg...