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Alejandra Marinelarena

Explore the profile of Alejandra Marinelarena including associated specialties, affiliations and a list of published articles. Areas
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Articles 9
Citations 197
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Recent Articles
1.
Marinelarena A, Bhattacharya P, Kumar P, Maker A, Prabhakar B
Sci Rep . 2018 Oct; 8(1):14940. PMID: 30297856
We have previously shown GM-CSF derived bone-marrow dendritic cells (G-BMDCs) can induce the selective expansion of Tregs through the surface-bound molecule OX40L; however, the physiological role of this ex vivo...
2.
Kumar P, Marinelarena A, Raghunathan D, Ragothaman V, Saini S, Bhattacharya P, et al.
Cell Mol Immunol . 2018 Mar; 16(2):138-153. PMID: 29578532
Regulatory T cells (Tregs) play a pivotal role in immune-tolerance, and loss of Treg function can lead to the development of autoimmunity. Natural Tregs generated in the thymus substantially contribute...
3.
Alharshawi K, Marinelarena A, Kumar P, El-Sayed O, Bhattacharya P, Sun Z, et al.
Sci Rep . 2017 Jul; 7(1):6594. PMID: 28747670
We have previously shown that OX40L/OX40 interaction is critical for TCR-independent selective proliferation of Foxp3 Tregs, but not Foxp3 effector T-cells (Teff), when CD4 T-cells are co-cultured with GM-CSF derived...
4.
Kumar P, Alharshawi K, Bhattacharya P, Marinelarena A, Haddad C, Sun Z, et al.
Sci Rep . 2017 Jan; 7:39751. PMID: 28045060
Regulatory T-cells (Tregs) play a pivotal role in maintaining peripheral tolerance. Increasing Treg numbers/functions has been shown to ameliorate autoimmune diseases. However, common Treg expansion approaches use T-Cell Receptor (TCR)-mediated...
5.
Haddad C, Bhattacharya P, Alharshawi K, Marinelarena A, Kumar P, El-Sayed O, et al.
Autoimmunity . 2016 Jun; 49(5):298-311. PMID: 27245356
Earlier, we have shown that GM-CSF derived bone marrow (BM) dendritic cells (G-BMDCs) can expand Foxp3(+) regulatory T-cells (Tregs) through a TCR-independent, but IL-2 dependent mechanism that required OX40L/OX40 interaction....
6.
Traurig M, Hanson R, Marinelarena A, Kobes S, Piaggi P, Cole S, et al.
Diabetes . 2015 Oct; 65(2):510-9. PMID: 26487785
Genetic variants in SLC16A11 were recently reported to be associated with type 2 diabetes in Mexican and other Latin American populations. The diabetes risk haplotype had a frequency of 50%...
7.
Bian L, Traurig M, Hanson R, Marinelarena A, Kobes S, Muller Y, et al.
Hum Mol Genet . 2013 Jul; 22(21):4438-49. PMID: 23825110
To identify genes that affect body mass index (BMI) in American Indians who are predominately of Pima Indian heritage, we previously completed a genome-wide association study in 1120 American Indians....
8.
Ma L, Murea M, Snipes J, Marinelarena A, Kruger J, Hicks P, et al.
PLoS One . 2013 Mar; 8(2):e56193. PMID: 23460794
Acetyl coenzyme A carboxylase B gene (ACACB) single nucleotide polymorphism (SNP) rs2268388 is reproducibly associated with type 2 diabetes (T2DM)-associated nephropathy (DN). ACACB knock-out mice are also protected from obesity....
9.
Aguayo-Mazzucato C, Zavacki A, Marinelarena A, Hollister-Lock J, El Khattabi I, Marsili A, et al.
Diabetes . 2013 Jan; 62(5):1569-80. PMID: 23305647
Neonatal β cells do not secrete glucose-responsive insulin and are considered immature. We previously showed the transcription factor MAFA is key for the functional maturation of β cells, but the...