Alec B Wilkens
Overview
Explore the profile of Alec B Wilkens including associated specialties, affiliations and a list of published articles.
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Articles
4
Citations
994
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Recent Articles
1.
Minnie S, Waltner O, Zhang P, Takahashi S, Nemychenkov N, Ensbey K, et al.
Sci Immunol
. 2024 Apr;
9(94):eadg1094.
PMID: 38640253
Chronic antigen stimulation is thought to generate dysfunctional CD8 T cells. Here, we identify a CD8 T cell subset in the bone marrow tumor microenvironment that, despite an apparent terminally...
2.
Wilkens A, Fulton E, Pont M, Cole G, Leung I, Stull S, et al.
Blood
. 2022 May;
140(21):2261-2275.
PMID: 35605191
Adoptive transfer of T cells expressing chimeric antigen receptors (CAR-T) effectively treats refractory hematologic malignancies in a subset of patients but can be limited by poor T-cell expansion and persistence...
3.
Dever D, Bak R, Reinisch A, Camarena J, Washington G, Nicolas C, et al.
Nature
. 2016 Nov;
539(7629):384-389.
PMID: 27820943
The β-haemoglobinopathies, such as sickle cell disease and β-thalassaemia, are caused by mutations in the β-globin (HBB) gene and affect millions of people worldwide. Ex vivo gene correction in patient-derived...
4.
Hendel A, Bak R, Clark J, Kennedy A, Ryan D, Roy S, et al.
Nat Biotechnol
. 2015 Jun;
33(9):985-989.
PMID: 26121415
CRISPR-Cas-mediated genome editing relies on guide RNAs that direct site-specific DNA cleavage facilitated by the Cas endonuclease. Here we report that chemical alterations to synthesized single guide RNAs (sgRNAs) enhance...