Albrecht Buchmann
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Explore the profile of Albrecht Buchmann including associated specialties, affiliations and a list of published articles.
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31
Citations
643
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Recent Articles
1.
Braeuning A, Bucher P, Hofmann U, Buchmann A, Schwarz M
BMC Cancer
. 2014 Oct;
14:766.
PMID: 25319454
Background: Atorvastatin is a potent inhibitor of the mevalonate pathway and widely used as a hypolipidemic drug. Some epidemiological studies and animal experiments indicate that the long-term use of atorvastatin...
2.
Rignall B, Grote K, Gavrilov A, Weimer M, Kopp-Schneider A, Krause E, et al.
Toxicol Sci
. 2013 Mar;
133(1):29-41.
PMID: 23457121
To assess the impact of a mixture containing dioxin-like and non-dioxin-like polychlorinated biphenyls (PCBs), male mice were initiated with N-nitroso-diethylamine and subsequently treated with PCB126, an Ah-Receptor agonist, and PCB153,...
3.
Schreiber S, Rignall B, Braeuning A, Marx-Stoelting P, Ott T, Buchmann A, et al.
J Mol Histol
. 2011 Aug;
42(5):393-400.
PMID: 21822615
The gene CTNNB1 encoding β-catenin is mutated in about 30% of hepatocellular carcinoma, generally often combined with other genetic alterations. In transgenic mice, it has been shown that activation of...
4.
Braeuning A, Kohle C, Buchmann A, Schwarz M
Toxicol Sci
. 2011 Apr;
122(1):16-25.
PMID: 21498875
The expression of cytochrome P450 (CYP) 1a1 and other drug-metabolizing enzymes is controlled by the aryl hydrocarbon receptor (AhR), which is activated by dioxin-type inducers leading to transcriptional induction of...
5.
Rignall B, Braeuning A, Buchmann A, Schwarz M
Carcinogenesis
. 2010 Nov;
32(1):52-7.
PMID: 21047994
The antiepileptic drug phenobarbital (PB) is a potent tumor promoter in mouse liver, where it stimulates the selective outgrowth of tumor populations harboring activating mutations in Ctnnb1, encoding β-catenin. A...
6.
Braeuning A, Singh Y, Rignall B, Buchmann A, Hammad S, Othman A, et al.
Histochem Cell Biol
. 2010 Oct;
134(5):469-81.
PMID: 20886225
Signaling through the Wnt/β-catenin pathway is a crucial determinant of hepatic zonal gene expression, liver development, regeneration, and tumorigenesis. Transgenic mice with hepatocyte-specific knockout of Ctnnb1 (encoding β-catenin) have proven...
7.
Giera S, Braeuning A, Kohle C, Bursch W, Metzger U, Buchmann A, et al.
Toxicol Sci
. 2010 Feb;
115(1):22-33.
PMID: 20118494
Glutathione S-transferases (GSTs) play an essential role in the elimination of xenobiotic-derived electrophilic metabolites and also catalyze certain steps in the conversion of endogenous molecules. Their expression is controlled by...
8.
Rignall B, Ittrich C, Krause E, Appel K, Buchmann A, Schwarz M
J Proteome Res
. 2009 May;
8(8):3987-94.
PMID: 19476384
Mouse liver tumors frequently harbor activating mutations in the Ha-ras protooncogene. In addition, mutations are also found in the B-raf gene leading to constitutive activation of the B-Raf kinase. In...
9.
Braeuning A, Buchmann A
Drug Metab Dispos
. 2009 May;
37(8):1576-80.
PMID: 19448134
Kinase inhibitors are frequently used tools in signal transduction research. 3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione (SB216763), a potent inhibitor of glycogen synthase kinase 3beta (GSK3beta), is frequently used to activate beta-catenin signaling by mimicking...
10.
Marx-Stoelting P, Borowiak M, Knorpp T, Birchmeier C, Buchmann A, Schwarz M
Int J Cancer
. 2009 Jan;
124(8):1767-72.
PMID: 19123478
The receptor for the hepatocyte growth factor/scatter factor (HGF/SF), c-Met, plays a role in tumour promotion, progression and metastasis. In this study, we analysed chemically induced hepatocarcinogenesis in mice lacking...