Alberto Marin-Gonzalez
Overview
Explore the profile of Alberto Marin-Gonzalez including associated specialties, affiliations and a list of published articles.
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11
Citations
109
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Recent Articles
1.
Marin-Gonzalez A, Rybczynski A, Nilavar N, Nguyen D, Karwacki-Neisius V, Li A, et al.
bioRxiv
. 2025 Feb;
PMID: 39990468
Cohesin folds genomes into chromatin loops, whose roles are under debate. We report that double strand breaks (DSB) induce formation of chromatin loops, with the break positioned at the loop...
2.
Helms R, Marin-Gonzalez A, Patel C, Sun I, Wen J, Leone R, et al.
J Immunol
. 2023 Nov;
211(12):1767-1782.
PMID: 37947442
Understanding the mechanisms underlying the acquisition and maintenance of effector function during T cell differentiation is important to unraveling how these processes can be dysregulated in the context of disease...
3.
Deshpande R, Marin-Gonzalez A, Barnes H, Woolley P, Ha T, Paull T
Nat Commun
. 2023 Sep;
14(1):5759.
PMID: 37717054
The Mre11-Rad50-Nbs1 (MRN) complex recognizes and processes DNA double-strand breaks for homologous recombination by performing short-range removal of 5' strands. Endonucleolytic processing by MRN requires a stably bound protein at...
4.
Zou R, Liu Y, Reyes Gaido O, Konig M, Mog B, Shen L, et al.
Nat Methods
. 2023 Apr;
20(5):706-713.
PMID: 37024653
Discovery of off-target CRISPR-Cas activity in patient-derived cells and animal models is crucial for genome editing applications, but currently exhibits low sensitivity. We demonstrate that inhibition of DNA-dependent protein kinase...
5.
Zou R, Marin-Gonzalez A, Liu Y, Liu H, Shen L, Dveirin R, et al.
Nat Cell Biol
. 2022 Sep;
24(9):1433-1444.
PMID: 36064968
Here we present an approach that combines a clustered regularly interspaced short palindromic repeats (CRISPR) system that simultaneously targets hundreds of epigenetically diverse endogenous genomic sites with high-throughput sequencing to...
6.
Kannan A, Suomalainen M, Volle R, Bauer M, Amsler M, Trinh H, et al.
Viruses
. 2022 Jul;
14(7).
PMID: 35891387
Pathogen-associated molecular patterns, including cytoplasmic DNA and double-strand (ds)RNA trigger the induction of interferon (IFN) and antiviral states protecting cells and organisms from pathogens. Here we discovered that the transfection...
7.
Marin-Gonzalez A, Vilhena J, Perez R, Moreno-Herrero F
Q Rev Biophys
. 2021 Jul;
54:e8.
PMID: 34225835
DNA dynamics can only be understood by taking into account its complex mechanical behavior at different length scales. At the micrometer level, the mechanical properties of single DNA molecules have...
8.
Marin-Gonzalez A, Aicart-Ramos C, Marin-Baquero M, Martin-Gonzalez A, Suomalainen M, Kannan A, et al.
Nucleic Acids Res
. 2020 Nov;
48(22):12917-12928.
PMID: 33245767
Sequence-dependent structural deformations of the DNA double helix (dsDNA) have been extensively studied, where adenine tracts (A-tracts) provide a striking example for global bending in the molecule. However, in contrast...
9.
Marin-Gonzalez A, Pastrana C, Bocanegra R, Martin-Gonzalez A, Vilhena J, Perez R, et al.
Nucleic Acids Res
. 2020 Apr;
48(9):5024-5036.
PMID: 32282908
A-tracts are A:T rich DNA sequences that exhibit unique structural and mechanical properties associated with several functions in vivo. The crystallographic structure of A-tracts has been well characterized. However, the...
10.
Marin-Gonzalez A, Vilhena J, Moreno-Herrero F, Perez R
Nanoscale
. 2019 Nov;
11(44):21471-21478.
PMID: 31686065
The mechanical properties of double-stranded RNA (dsRNA) are involved in many of its biological functions and are relevant for future nanotechnology applications. DsRNA must tightly bend to fit inside viral...