Alberto C Vitari
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Explore the profile of Alberto C Vitari including associated specialties, affiliations and a list of published articles.
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10
Citations
2010
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Recent Articles
1.
McDonald 3rd E, de Weck A, Schlabach M, Billy E, Mavrakis K, Hoffman G, et al.
Cell
. 2017 Jul;
170(3):577-592.e10.
PMID: 28753431
Elucidation of the mutational landscape of human cancer has progressed rapidly and been accompanied by the development of therapeutics targeting mutant oncogenes. However, a comprehensive mapping of cancer dependencies has...
2.
Mavrakis K, McDonald 3rd E, Schlabach M, Billy E, Hoffman G, deWeck A, et al.
Science
. 2016 Feb;
351(6278):1208-13.
PMID: 26912361
5-Methylthioadenosine phosphorylase (MTAP) is a key enzyme in the methionine salvage pathway. The MTAP gene is frequently deleted in human cancers because of its chromosomal proximity to the tumor suppressor...
3.
Thastrup J, Rafiqi F, Vitari A, Pozo-Guisado E, Deak M, Mehellou Y, et al.
Biochem J
. 2011 Oct;
441(1):325-37.
PMID: 22032326
Mutations in the WNK [with no lysine (K) kinase] family instigate hypertension and pain perception disorders. Of the four WNK isoforms, much of the focus has been on WNK1, which...
4.
Vitari A, Leong K, Newton K, Yee C, ORourke K, Liu J, et al.
Nature
. 2011 May;
474(7351):403-6.
PMID: 21572435
The proto-oncogenes ETV1, ETV4 and ETV5 encode transcription factors in the E26 transformation-specific (ETS) family, which includes the most frequently rearranged and overexpressed genes in prostate cancer. Despite being critical...
5.
Lamkanfi M, Sarkar A, Vande Walle L, Vitari A, Amer A, Wewers M, et al.
J Immunol
. 2010 Aug;
185(7):4385-92.
PMID: 20802146
Endotoxin administration recapitulates many of the host responses to sepsis. Inhibitors of the cysteine protease caspase 1 have long been sought as a therapeutic because mice lacking caspase 1 are...
6.
Lamkanfi M, Mueller J, Vitari A, Misaghi S, Fedorova A, Deshayes K, et al.
J Cell Biol
. 2009 Oct;
187(1):61-70.
PMID: 19805629
Inflammasomes activate caspase-1 for processing and secretion of the cytokines interleukin-1beta (IL-1beta) and IL-18. Cryopyrin/NALP3/NLRP3 is an essential component of inflammasomes triggered by microbial ligands, danger-associated molecular patterns (DAMPs), and...
7.
Zagorska A, Pozo-Guisado E, Boudeau J, Vitari A, Rafiqi F, Thastrup J, et al.
J Cell Biol
. 2006 Dec;
176(1):89-100.
PMID: 17190791
Mutations within the WNK1 (with-no-K[Lys] kinase-1) gene cause Gordon's hypertension syndrome. Little is known about how WNK1 is regulated. We demonstrate that WNK1 is rapidly activated and phosphorylated at multiple...
8.
Vitari A, Thastrup J, Rafiqi F, Deak M, Morrice N, Karlsson H, et al.
Biochem J
. 2006 May;
397(1):223-31.
PMID: 16669787
The SPAK (STE20/SPS1-related proline/alanine-rich kinase) and OSR1 (oxidative stress-responsive kinase-1) kinases interact and phosphorylate NKCC1 (Na+-K+-2Cl- co-transporter-1), leading to its activation. Recent studies indicated that SPAK and OSR1 are phosphorylated...
9.
Vitari A, Deak M, Morrice N, Alessi D
Biochem J
. 2005 Aug;
391(Pt 1):17-24.
PMID: 16083423
Mutations in the human genes encoding WNK1 [with no K (lysine) protein kinase-1] and the related protein kinase WNK4 are the cause of Gordon's hypertension syndrome. Little is known about...
10.
Vitari A, Deak M, Collins B, Morrice N, Prescott A, Phelan A, et al.
Biochem J
. 2003 Nov;
378(Pt 1):257-68.
PMID: 14611643
Recent evidence indicates that mutations in the gene encoding the WNK1 [with no K (lysine) protein kinase-1] results in an inherited hypertension syndrome called pseudohypoaldosteronism type II. The mechanisms by...