Albert H Chan
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Explore the profile of Albert H Chan including associated specialties, affiliations and a list of published articles.
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21
Citations
266
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Recent Articles
1.
Maciag A, Stice J, Wang B, Sharma A, Chan A, Lin K, et al.
Cancer Discov
. 2024 Dec;
15(3):578-594.
PMID: 39642212
Approved inhibitors of KRASG12C prevent oncogenic activation by sequestering the inactive, GDP-bound (OFF) form rather than directly binding and inhibiting the active, GTP-bound (ON) form. This approach provides no direct...
2.
Chan A, Simanshu D
Methods Mol Biol
. 2024 Apr;
2797:47-65.
PMID: 38570452
RAS proteins play a vital role in regulating downstream signaling and essential cellular processes, positioning them as key players in normal cellular physiology and disease development. Among the various isoforms...
3.
Hollander K, Chan A, Frey K, Hunker O, Ippolito J, Spasov K, et al.
Protein Sci
. 2023 Oct;
32(12):e4814.
PMID: 37861472
HIV-1 reverse transcriptase (RT) remains a key target for HIV drug development. As successful management of the disease requires lifelong treatment, the emergence of resistance mutations is inevitable, making development...
4.
Chao F, Chan A, Dharmaiah S, Schwieters C, Tran T, Taylor T, et al.
Commun Biol
. 2023 Jun;
6(1):594.
PMID: 37268708
Localized dynamics of RAS, including regions distal to the nucleotide-binding site, is of high interest for elucidating the mechanisms by which RAS proteins interact with effectors and regulators and for...
5.
Lopez C, Zhang X, Aydin F, Shrestha R, Van Q, Stanley C, et al.
J Chem Theory Comput
. 2022 Jul;
18(8):5025-5045.
PMID: 35866871
The appeal of multiscale modeling approaches is predicated on the promise of combinatorial synergy. However, this promise can only be realized when distinct scales are combined with reciprocal consistency. Here,...
6.
Nguyen K, Lopez C, Neale C, Van Q, Carpenter T, Di Natale F, et al.
Biophys J
. 2022 Jul;
121(19):3630-3650.
PMID: 35778842
During the activation of mitogen-activated protein kinase (MAPK) signaling, the RAS-binding domain (RBD) and cysteine-rich domain (CRD) of RAF bind to active RAS at the plasma membrane. The orientation of...
7.
Frey K, Bertoletti N, Chan A, Ippolito J, Bollini M, Spasov K, et al.
Front Mol Biosci
. 2022 Mar;
9:805187.
PMID: 35237658
Reverse transcriptase (RT) from the human immunodeficiency virus continues to be an attractive drug target for antiretroviral therapy. June 2022 will commemorate the 30th anniversary of the first Human Immunodeficiency...
8.
Tran T, Chan A, Young L, Bindu L, Neale C, Messing S, et al.
Nat Commun
. 2021 Feb;
12(1):1176.
PMID: 33608534
The first step of RAF activation involves binding to active RAS, resulting in the recruitment of RAF to the plasma membrane. To understand the molecular details of RAS-RAF interaction, we...
9.
Bertoletti N, Chan A, Schinazi R, Anderson K
Molecules
. 2020 Oct;
25(20).
PMID: 33096918
Human immunodeficiency virus 1 (HIV-1) infection is a global health issue since neither a cure nor a vaccine is available. However, the highly active antiretroviral therapy (HAART) has improved the...
10.
Duong V, Ippolito J, Chan A, Lee W, Spasov K, Jorgensen W, et al.
Protein Sci
. 2020 Jul;
29(9):1902-1910.
PMID: 32643196
Human immunodeficiency virus (HIV)-1 remains as a global health issue that is primarily treated with highly active antiretroviral therapy, a combination of drugs that target the viral life cycle. One...