Alanna C Morrison
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Explore the profile of Alanna C Morrison including associated specialties, affiliations and a list of published articles.
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288
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15418
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Recent Articles
11.
Sarnowski C, Ma J, Nguyen N, Hoogeveen R, Ballantyne C, Coresh J, et al.
medRxiv
. 2024 Oct;
PMID: 39399032
Fully characterizing the genetic architecture of circulating proteins in multi-ancestry populations provides an unprecedented opportunity to gain insights into the etiology of complex diseases. We characterized and contrasted the genetic...
12.
Rocheleau G, Clarke S, Auguste G, Hasbani N, Morrison A, Heath A, et al.
Nat Commun
. 2024 Oct;
15(1):8741.
PMID: 39384761
Whole genome sequences (WGS) enable discovery of rare variants which may contribute to missing heritability of coronary artery disease (CAD). To measure their contribution, we apply the GREML-LDMS-I approach to...
13.
Hahn J, Temprano-Sagrera G, Hasbani N, Ligthart S, Dehghan A, Wolberg A, et al.
J Thromb Haemost
. 2024 Sep;
22(12):3448-3459.
PMID: 39299614
Background: Fibrinogen and C-reactive protein (CRP) play an important role in inflammatory pathways and share multiple genetic loci reported in previously published genome-wide association studies (GWAS), highlighting their common genetic...
14.
Noordam R, Wang W, Nagarajan P, Wang H, Brown M, Bentley A, et al.
medRxiv
. 2024 Sep;
PMID: 39281768
We performed large-scale genome-wide gene-sleep interaction analyses of lipid levels to identify novel genetic variants underpinning the biomolecular pathways of sleep-associated lipid disturbances and to suggest possible druggable targets. We...
15.
Huffman J, Nicholas J, Hahn J, Heath A, Raffield L, Yanek L, et al.
Blood
. 2024 Sep;
144(21):2248-2265.
PMID: 39226462
Genetic studies have identified numerous regions associated with plasma fibrinogen levels in Europeans, yet missing heritability and limited inclusion of non-Europeans necessitates further studies with improved power and sensitivity. Compared...
16.
Dobson D, Fish R, de Vries P, Morrison A, Neerman-Arbez M, Wolberg A
Thromb Res
. 2024 Aug;
242:109134.
PMID: 39216273
The plasma protein fibrinogen is encoded by 3 structural genes (FGA, FGB, and FGG) that are transcribed to mRNA, spliced, and translated to 3 polypeptide chains (Aα, Bβ, and γ,...
17.
Stafford L, Tang X, Brandt A, Ma J, Banchs J, Livingston J, et al.
Pharmacogenomics J
. 2024 Jul;
24(4):21.
PMID: 38951505
There is a known genetic susceptibility to anthracycline-induced cardiac dysfunction in childhood cancer survivors, but this has not been adequately shown in adolescent and young adult (AYA) patients. Our aim...
18.
de Vries P, Conomos M, Singh K, Nicholson C, Jain D, Hasbani N, et al.
Nat Cardiovasc Res
. 2024 May;
2(12):1159-1172.
PMID: 38817323
Coronary artery calcification (CAC) is a measure of atherosclerosis and a well-established predictor of coronary artery disease (CAD) events. Here we describe a genome-wide association study (GWAS) of CAC in...
19.
Hrytsenko Y, Shea B, Elgart M, Kurniansyah N, Lyons G, Morrison A, et al.
Sci Rep
. 2024 May;
14(1):12436.
PMID: 38816422
We construct non-linear machine learning (ML) prediction models for systolic and diastolic blood pressure (SBP, DBP) using demographic and clinical variables and polygenic risk scores (PRSs). We developed a two-model...
20.
Keaton J, Kamali Z, Xie T, Vaez A, Williams A, Goleva S, et al.
Nat Genet
. 2024 Apr;
56(5):778-791.
PMID: 38689001
Hypertension affects more than one billion people worldwide. Here we identify 113 novel loci, reporting a total of 2,103 independent genetic signals (P < 5 × 10) from the largest...