Alana K Simorellis
Overview
Explore the profile of Alana K Simorellis including associated specialties, affiliations and a list of published articles.
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13
Citations
379
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Recent Articles
1.
Goswami J, Cardona J, Hsu D, Simorellis A, Wilson L, Dhar R, et al.
Lancet Infect Dis
. 2024 Nov;
PMID: 39608389
Background: Coadministration of a respiratory syncytial virus (RSV) vaccine with seasonal influenza or SARS-CoV-2 vaccines could reduce health-care visits and increase vaccination uptake in older adults who are at high...
2.
Panozzo C, Walsh E, Yang Z, Wilson E, Goswami J, Stoszek S, et al.
Infect Dis Ther
. 2024 Nov;
14(1):275-281.
PMID: 39549152
Introduction: As no standard case definitions for respiratory syncytial virus-associated lower respiratory tract disease (RSV-LRTD) in adults are available, this study analyzed definitions for severe RSV-LRTD from previously published data...
3.
Fitz-Patrick D, Mihara H, Mills A, Mithani R, Kapoor A, Dhar R, et al.
Respir Investig
. 2024 Sep;
62(6):1037-1043.
PMID: 39255587
Background: Respiratory syncytial virus (RSV) represents a global health concern, including in older adults. This study assessed the safety and immunogenicity of mRNA-1345, an investigational mRNA RSV vaccine, in adults...
4.
Shaw C, Essink B, Harper C, Mithani R, Kapoor A, Dhar R, et al.
J Infect Dis
. 2024 Feb;
230(3):e647-e656.
PMID: 38385566
Background: An mRNA-based respiratory syncytial virus (RSV) vaccine, mRNA-1345, is under clinical investigation to address RSV disease burden in older adults. Methods: Based on a randomized, observer-blind, placebo-controlled design, this...
5.
Wilson E, Goswami J, Baqui A, Doreski P, Perez-Marc G, Zaman K, et al.
N Engl J Med
. 2023 Dec;
389(24):2233-2244.
PMID: 38091530
Background: Respiratory syncytial virus (RSV) can cause substantial morbidity and mortality among older adults. An mRNA-based RSV vaccine, mRNA-1345, encoding the stabilized RSV prefusion F glycoprotein, is under clinical investigation....
6.
Kitahara R, Simorellis A, Hata K, Maeno A, Yokoyama S, Koide S, et al.
Biophys J
. 2012 Mar;
102(4):916-26.
PMID: 22385863
Outer surface protein A (OspA) is a crucial protein in the infection of Borrelia burgdorferi causing Lyme disease. We studied conformational fluctuations of OspA with high-pressure (15)N/(1)H two-dimensional NMR along...
7.
Wang W, Perovic I, Chittuluru J, Kaganovich A, Nguyen L, Liao J, et al.
Proc Natl Acad Sci U S A
. 2011 Oct;
108(43):17797-802.
PMID: 22006323
A heterologously expressed form of the human Parkinson disease-associated protein α-synuclein with a 10-residue N-terminal extension is shown to form a stable tetramer in the absence of lipid bilayers or...
8.
Pochapsky S, Dang M, Ouyang B, Simorellis A, Pochapsky T
Biochemistry
. 2009 Apr;
48(20):4254-61.
PMID: 19366254
Local protein backbone dynamics of the camphor hydroxylase cytochrome P450(cam) (CYP101) depend upon the oxidation and ligation state of the heme iron. (1)H-(15)N correlation nuclear magnetic resonance experiments were used...
9.
Hamuro Y, Molnar K, Coales S, Ouyang B, Simorellis A, Pochapsky T
J Inorg Biochem
. 2007 Nov;
102(2):364-70.
PMID: 18023482
Backbone dynamics of the camphor monoxygenase cytochrome P450(cam) (CYP101) as a function of oxidation/ligation state of the heme iron were investigated via hydrogen/deuterium exchange (H/D exchange) as monitored by mass...
10.
Simorellis A, Flynn P
J Am Chem Soc
. 2006 Jul;
128(30):9580-1.
PMID: 16866482
Backbone dynamics of ubiquitin confined within AOT reverse micelles have been evaluated based on analysis of 15N NMR relaxation data. Results indicate that upon encapsulation the protein experiences a slight...