Alan R Gintzler
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Explore the profile of Alan R Gintzler including associated specialties, affiliations and a list of published articles.
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43
Citations
517
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Recent Articles
1.
Storman E, Liu N, Gintzler A
J Neuroendocrinol
. 2022 Jan;
34(4):e13089.
PMID: 35043508
We previously reported that aromatase protein levels do not parallel aromatase enzyme activity. This suggests that oestrogenic signalling may be modulated via post-translational modification of aromatase protein. The tyrosine and...
2.
Gintzler A, Liu N
Transl Res
. 2021 Feb;
234:31-42.
PMID: 33567346
Nociception and opioid antinociception in females are pliable processes, varying qualitatively and quantitatively over the reproductive cycle. Spinal estrogenic signaling via membrane estrogen receptors (mERs), in combination with multiple other...
3.
Chakrabarti S, Liu N, Gintzler A
Cell Mol Neurobiol
. 2020 Aug;
41(5):855-862.
PMID: 32804312
Opioid dose escalation to effectively control pain is often linked to the current prescription opioid abuse epidemic. This creates social as well as medical imperatives to better understand the mechanistic...
4.
Gintzler A, Liu N
J Opioid Manag
. 2020 Feb;
16(1):67-72.
PMID: 32091619
Objective: To review evidence demonstrating efficacy and feasibility of harnessing the activity of endogenous opioid analgesic systems for pain management. Methods: The authors sought to summarize a wealth of data...
5.
Chakrabarti S, Liu N, Gintzler A
J Neurochem
. 2019 Sep;
152(4):449-467.
PMID: 31479519
We recently demonstrated in rat spinal cord that a regimen of escalating doses of systemic morphine, analogous to regimens used clinically for chronic pain management, selectively up-regulates the mu-opioid receptor...
6.
Gintzler A, Storman E, Liu N
Vitam Horm
. 2019 Aug;
111:227-246.
PMID: 31421702
The organization of estrogenic signaling in the CNS is exceedingly complex. It is comprised of peripherally and centrally synthesized estrogens, and a plethora of types of estrogen receptor that can...
7.
Gintzler A, Liu N, Storman E, Wessendorf M
Peptides
. 2018 Dec;
112:133-138.
PMID: 30557590
Effective management of chronic pain is demanded by ethical as well as medical considerations. Although opioid analgesics remain among the most effective pharmacotherapies for ameliorating many types of pain, their...
8.
Liu N, Storman E, Gintzler A
J Pain
. 2018 Oct;
20(2):235-243.
PMID: 30366152
We showed previously that spinal metabotropic glutamate receptor 1 (mGluR) signaling suppresses or facilitates (depending on the stage of estrous cycle) analgesic responsiveness to intrathecal endomorphin 2, a highly mu-opioid...
9.
Storman E, Liu N, Wessendorf M, Gintzler A
Endocrinology
. 2018 May;
159(7):2683-2697.
PMID: 29771302
Rapid-signaling membrane estrogen receptors (mERs) and aromatase (Aro) are present throughout the central nervous system (CNS), enabling acute regulation of CNS estrogenic signaling. We previously reported that spinal membrane Aro...
10.
Liu N, Murugaiyan V, Storman E, Schnell S, Kumar A, Wessendorf M, et al.
J Neurosci
. 2017 Oct;
37(46):11181-11191.
PMID: 29025923
We previously showed that intrathecal application of endomorphin 2 [EM2; the highly specific endogenous μ-opioid receptor (MOR) ligand] induces antinociception that varies with stage of the rat estrous cycle: minimal...