Alan M Kwong
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Explore the profile of Alan M Kwong including associated specialties, affiliations and a list of published articles.
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9
Citations
881
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Recent Articles
1.
Kwong A, Blackwell T, LeFaive J, de Andrade M, Barnard J, Barnes K, et al.
Genetics
. 2021 Mar;
218(1.
PMID: 33720349
Traditional Hardy-Weinberg equilibrium (HWE) tests (the χ2 test and the exact test) have long been used as a metric for evaluating genotype quality, as technical artifacts leading to incorrect genotype...
2.
Brieger K, Zajac G, Pandit A, Foerster J, Li K, Annis A, et al.
Am J Hum Genet
. 2019 Aug;
105(2):441-442.
PMID: 31374205
No abstract available.
3.
Brieger K, Zajac G, Pandit A, Foerster J, Li K, Annis A, et al.
Am J Hum Genet
. 2019 Jun;
105(1):65-77.
PMID: 31204010
The Genes for Good study uses social media to engage a large, diverse participant pool in genetics research and education. Health history and daily tracking surveys are administered through a...
4.
Fritsche L, Igl W, Cooke Bailey J, Grassmann F, Sengupta S, Bragg-Gresham J, et al.
Nat Genet
. 2015 Dec;
48(2):134-43.
PMID: 26691988
Advanced age-related macular degeneration (AMD) is the leading cause of blindness in the elderly, with limited therapeutic options. Here we report on a study of >12 million variants, including 163,714...
5.
Tippin B, Kwong A, Inadomi M, Lee O, Park J, Materi A, et al.
Cancer Med
. 2014 Apr;
3(4):1041-51.
PMID: 24729479
Our earlier work showed that knockout of hematopoietic prostaglandin D synthase (HPGDS, an enzyme that produces prostaglandin D2) caused more adenomas in Apc(Min/+) mice. Conversely, highly expressed transgenic HPGDS allowed...
6.
Tippin B, Levine A, Materi A, Song W, Keku T, Goodman J, et al.
Prostaglandins Other Lipid Mediat
. 2011 Aug;
97(1-2):22-8.
PMID: 21821144
Intestinal tumors in Apc(Min/+) mice are suppressed by over-production of HPGDS, which is a glutathione transferase that forms prostaglandin D(2) (PGD(2)). We characterized naturally occurring HPGDS isoenzymes, to see if...
7.
Kwong A, Tippin B, Materi A, Buslon V, French S, Lin H
Nutr Cancer
. 2011 Jul;
63(6):950-9.
PMID: 21774590
High doses of niacin (nicotinic acid) used to treat dyslipidemias cause flushing, due to high levels of prostaglandin D(2) (PGD(2)). GPR109A, a G-protein coupled receptor, triggers the flushing in the...
8.
Lin H, Neidich J, Salazar D, Thomas-Johnson E, Ferreira B, Kwong A, et al.
J Pediatr
. 2009 Nov;
155(6):924-7.
PMID: 19914430
A symptom-free woman gave birth to a girl with a low carnitine level on newborn screening. The baby was unaffected, but the mother had biochemical abnormalities and mutations characteristic of...
9.
Park J, Kanaoka Y, Eguchi N, Aritake K, Grujic S, Materi A, et al.
Cancer Res
. 2007 Feb;
67(3):881-9.
PMID: 17283118
Aspirin and other nonsteroidal anti-inflammatory drugs prevent some cases of colon cancer by inhibiting prostaglandin (PG) synthesis. PGE(2) promotes colon neoplasia, as shown by knockout mouse studies on enzymes and...