Alan Landay
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Explore the profile of Alan Landay including associated specialties, affiliations and a list of published articles.
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201
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Recent Articles
1.
Shaikh M, Singh S, Giron L, Zhang L, Shankaran S, Engen P, et al.
J Infect Dis
. 2025 Mar;
PMID: 40048617
People with HIV (PWH) experience chronic intestinal barrier dysfunction which contributes to chronic inflammation and its comorbidities. The mechanisms underlying this phenomenon remain unclear. We hypothesize that living with HIV...
2.
Byrne J, Saini G, Garcia-Leon A, Alalwan D, Doran P, Landay A, et al.
EBioMedicine
. 2025 Feb;
113:105622.
PMID: 39987746
Background: The Mpox outbreak, caused by Monkeypox virus (MPXV), underscores the need for a serological assay to assess Mpox immunity. Modified Vaccinia Ankara (MVA) vaccine, an attenuated vaccinia virus (VACV),...
3.
Associations between the gut microbiome, inflammation and cardiovascular profiles in people with HIV
MacCann R, Li J, Leon A, Negi R, Alalwan D, Tinago W, et al.
J Infect Dis
. 2025 Jan;
PMID: 39854172
Background: Inflammation and innate immune activation are associated with chronic HIV infection, despite effective treatment. Although gut microbiota alterations are linked to systemic inflammation, the relationships between the gut microbiome,...
4.
Mac Cann R, Newman E, Devane D, Sabin C, Cotter A, Landay A, et al.
PLoS One
. 2024 Dec;
19(12):e0308859.
PMID: 39652612
Background: Effective antiretroviral therapy (ART) has improved the life expectancy of people with HIV (PWH). However, this population is now experiencing accelerated age-related comorbidities, contributed to by chronic immune activation...
5.
Vanpouille C, Wells A, DeGruttola V, Lynch M, Zhang X, Fitzgerald W, et al.
AIDS
. 2024 Dec;
39(1):1-10.
PMID: 39639719
Objective: Although antiretroviral therapy (ART) suppresses viral replication and reduces inflammation, it does not lead to the normalization of cytokines. The long-term effects of ART beyond viral suppression have not...
6.
Ruderman S, Hunt P, Beck-Engeser G, Ambayec G, Willig A, Saag M, et al.
AIDS
. 2024 Oct;
39(2):153-161.
PMID: 39453872
Background: Frailty occurs at higher rates and younger ages among people with HIV (PWH) compared with the general population and is often attributed to chronic inflammation and subsequent immune exhaustion....
7.
Byrne J, Gu L, Garcia-Leon A, Gaillard C, Saini G, Alalwan D, et al.
Front Immunol
. 2024 Oct;
15:1445653.
PMID: 39355249
Introduction: A clear immune correlate of protection from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has not been defined. We explored antibody, B-cell, and T-cell responses to the third-dose...
8.
Paul M, Choudhary M, Heaps A, Deo R, Moisi D, Gordon K, et al.
Pathog Immun
. 2024 Sep;
9(2):79-93.
PMID: 39247686
Background: Anti-SARS-CoV-2 monoclonal antibodies (mAbs) have played a key role as an anti-viral against SARS-CoV-2, but there is a potential for resistance to develop. The interplay between host antibody responses...
9.
Kenny G, Saini G, Gaillard C, Negi R, Alalwan D, Leon A, et al.
Heliyon
. 2024 Aug;
10(15):e34694.
PMID: 39144942
Background: The inflammatory changes that underlie the heterogeneous presentations of COVID-19 remain incompletely understood. In this study we aimed to identify inflammatory profiles that precede the development of severe COVID-19,...
10.
Hamilton J, Baccile R, Best T, Desai P, Landay A, Rojas J, et al.
J Clin Med
. 2024 Jun;
13(12).
PMID: 38929961
(1) : Dexmedetomidine is a sedative for patients receiving invasive mechanical ventilation (IMV) that previous single-site studies have found to be associated with improved survival in patients with COVID-19. The...