Alan H Stephenson
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Explore the profile of Alan H Stephenson including associated specialties, affiliations and a list of published articles.
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36
Citations
907
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Recent Articles
1.
Knebel S, Sprague R, Stephenson A
Prostaglandins Other Lipid Mediat
. 2015 Jan;
116-117:131-5.
PMID: 25617843
Inappropriate platelet aggregation can result in thrombosis and tissue ischemia. When compared to healthy human platelets, those of humans with type 2 diabetes (DM2) exhibit increased aggregation when stimulated. Activation...
2.
Richards J, Bowles E, Gordon W, Ellsworth M, Stephenson A, Sprague R
Am J Physiol Regul Integr Comp Physiol
. 2015 Jan;
308(5):R411-8.
PMID: 25552662
The circulating erythrocyte, by virtue of the regulated release of ATP in response to reduced oxygen (O2) tension, plays a key role in maintaining appropriate perfusion distribution to meet tissue...
3.
Bowles E, Moody G, Yeragunta Y, Stephenson A, Ellsworth M, Sprague R
Exp Biol Med (Maywood)
. 2014 Aug;
240(1):121-7.
PMID: 25125498
Both prostacyclin analogs and phosphodiesterase 5 (PDE5) inhibitors are effective treatments for pulmonary arterial hypertension (PAH). In addition to direct effects on vascular smooth muscle, prostacyclin analogs increase cAMP levels...
4.
Richards J, Yosten G, Kolar G, Jones C, Stephenson A, Ellsworth M, et al.
Am J Physiol Regul Integr Comp Physiol
. 2014 Aug;
307(7):R862-8.
PMID: 25080497
ATP release from erythrocytes in response to reduced oxygen (O2) tension stimulates local vasodilation, enabling these cells to direct perfusion to areas in skeletal muscle in need of O2. Erythrocytes...
5.
Richards J, Stephenson A, Ellsworth M, Sprague R
Am J Physiol Regul Integr Comp Physiol
. 2013 Oct;
305(11):R1331-6.
PMID: 24089376
Erythrocytes participate in the matching of oxygen (O2) delivery with local need in skeletal muscle via the release of O2 and the vasodilator, ATP. It was reported that a concentration...
6.
Knebel S, Elrick M, Bowles E, Zdanovec A, Stephenson A, Ellsworth M, et al.
Exp Biol Med (Maywood)
. 2013 Aug;
238(9):1069-74.
PMID: 23986226
Prostacyclin (PGI2) and phosphodiesterase 5 (PDE5) inhibitors are potent vasodilators that are used alone and in combination for the treatment of pulmonary arterial hypertension (PAH). Although these vasodilators are known...
7.
Goldman D, Fraser G, Ellis C, Sprague R, Ellsworth M, Stephenson A
Front Physiol
. 2012 Aug;
3:246.
PMID: 22934004
Integration of the numerous mechanisms that have been suggested to contribute to optimization of O(2) supply to meet O(2) need in skeletal muscle requires a systems biology approach which permits...
8.
Sridharan M, Bowles E, Richards J, Krantic M, Davis K, Dietrich K, et al.
Am J Physiol Heart Circ Physiol
. 2011 Dec;
302(3):H553-9.
PMID: 22159995
Erythrocytes have been implicated as controllers of vascular caliber by virtue of their ability to release the vasodilator ATP in response to local physiological and pharmacological stimuli. The regulated release...
9.
Sprague R, Bowles E, Achilleus D, Stephenson A, Ellis C, Ellsworth M
Am J Physiol Heart Circ Physiol
. 2011 Oct;
301(6):H2466-72.
PMID: 21963837
Erythrocytes, via release of ATP in areas of low oxygen (O(2)) tension, are components of a regulatory system for the distribution of perfusion in skeletal muscle ensuring optimal O(2) delivery...
10.
Bowden J, Shao F, Albert C, Lally J, Brown R, Procknow J, et al.
Lipids
. 2011 Sep;
46(12):1169-79.
PMID: 21904795
Cholesteryl esters (CE) are important lipid storage molecules. The present study demonstrates that sodiated adducts of CE molecular species form positive ions that can be detected in both survey scan...