Alan Cunningham
Overview
Explore the profile of Alan Cunningham including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
175
Followers
0
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Recent Articles
1.
Mollan S, Menon V, Cunningham A, Plant G, Bennetto L, Wong S, et al.
Eye (Lond)
. 2024 May;
38(12):2235-2237.
PMID: 38778141
No abstract available.
2.
Cunningham A, Oudejans L, Geugien M, Pereira-Martins D, Wierenga A, Erdem A, et al.
Blood Adv
. 2023 Oct;
8(1):56-69.
PMID: 37906522
Cysteine is a nonessential amino acid required for protein synthesis, the generation of the antioxidant glutathione, and for synthesizing the nonproteinogenic amino acid taurine. Here, we highlight the broad sensitivity...
3.
Vilaplana-Lopera N, Cuminetti V, Almaghrabi R, Papatzikas G, Rout A, Jeeves M, et al.
Elife
. 2022 Sep;
11.
PMID: 36052997
Acute myeloid leukaemia (AML) cells interact and modulate components of their surrounding microenvironment into their own benefit. Stromal cells have been shown to support AML survival and progression through various...
4.
Cunningham A, Erdem A, Alshamleh I, Geugien M, Pruis M, Pereira-Martins D, et al.
Blood
. 2022 Aug;
140(19):2037-2052.
PMID: 35984907
Targeting altered tumor cell metabolism might provide an attractive opportunity for patients with acute myeloid leukemia (AML). An amino acid dropout screen on primary leukemic stem cells and progenitor populations...
5.
Chen Y, Cunningham A, Kotagiri A
J Pediatr Ophthalmol Strabismus
. 2022 May;
60(1):52-59.
PMID: 35611824
Purpose: To explore the clinical features of laser pointer-related retinal injuries among children and gain insight into the general public awareness around laser pointer use. Methods: This was a retrospective...
6.
Erdem A, Marin S, Pereira-Martins D, Geugien M, Cunningham A, Pruis M, et al.
Nat Commun
. 2022 Apr;
13(1):2013.
PMID: 35440568
Metabolic programs can differ substantially across genetically distinct subtypes of acute myeloid leukemia (AML). These programs are not static entities but can change swiftly as a consequence of extracellular changes...
7.
Erdem A, Marin S, Pereira-Martins D, Cortes R, Cunningham A, Pruis M, et al.
Nat Commun
. 2022 Mar;
13(1):1105.
PMID: 35232995
Acute myeloid leukemia remains difficult to treat due to strong genetic heterogeneity between and within individual patients. Here, we show that Pyruvate dehydrogenase kinase 1 (PDK1) acts as a targetable...
8.
Wierenga A, Cunningham A, Erdem A, Lopera N, Brouwers-Vos A, Pruis M, et al.
Cancer Metab
. 2020 Jan;
7:11.
PMID: 31890203
Background: Hypoxia-inducible factors (HIF)1 and 2 are transcription factors that regulate the homeostatic response to low oxygen conditions. Since data related to the importance of HIF1 and 2 in hematopoietic...
9.
Cunningham A, Kotagiri A
BMC Ophthalmol
. 2018 Sep;
18(Suppl 1):228.
PMID: 30255792
Background: Dense Deposit Disease is a rare condition affecting the Bruch's membrane and the glomerular basement membrane. We report the progression of the ocular manifestations over a 30 year follow...
10.
Mooney C, Cunningham A, Tsapogas P, Toellner K, Brown G
Int J Mol Sci
. 2017 May;
18(5).
PMID: 28498310
The fms-like tyrosine kinase 3 (Flt3) is a cell surface receptor that is expressed by various hematopoietic progenitor cells (HPC) and Flt3-activating mutations are commonly present in acute myeloid and...