Alain Collas

A bottom-up approach was investigated to produce long-acting injectable (LAI) suspension-based formulations to overcome specific limitations of top-down manufacturing methods by tailoring drug characteristics while making the methods more sustainable...

Bottom-up production of active pharmaceutical ingredient (API) crystal suspensions offers advantages in surface property control and operational ease over top-down methods. However, downstream separation and concentration pose challenges. This proof-of-concept...

Long-acting crystal suspensions of active pharmaceutical ingredients (API) mostly comprised of an API, a suspension media (water) and excipients and provide sustained API release over time. Excipients are crucial for...

Our present work elucidated the operational feasibility of direct generation and stabilization of long-acting injectable (LAI) suspensions of a practically insoluble drug, itraconazole (ITZ), by combining continuous liquid antisolvent crystallization...

The title compound, C(23)H(17)F(5)N(2)O(3), forms a layered centrosymmetric crystal structure in which C-H⋯F inter-actions are responsible for the formation of planar ribbons along [110], meth-oxy-meth-oxy (C-H⋯O) inter-actions for the formation...

The solid-state structures of three push-pull acceptor-π-donor (A-π-D) systems differing only in the nature of the π-spacer have been determined. (E)-1-Nitro-4-[2-(3,4,5-trimethoxyphenyl)ethenyl]benzene, C(17)H(17)NO(5), (I), and its 'bridge-flipped' imine analogues, (E)-3,4,5-trimethoxy-N-(4-nitrobenzylidene)aniline, C(16)H(16)N(2)O(5),...

The title compound, C(32)H(30)O(4), crystallizes with three different conformers of the same mol-ecule in the asymmetric unit, which explains the unusually large unit cell volume. The supra-molecular structure is based...

In the title compound, C(11)H(12)O(6), the aldehyde group is disordered over two sites in a 0.79:0.21 ratio. The carb-oxy-lic acid chain is found in the [ap,ap] conformation due to two...

In the crystal of the title compound, C(15)H(8)N(4)O(6), the mol-ecules are organized in layers due to their linkage by weak C-H⋯N hydrogen bonds. The layers are themselves inter-connected by weak...

In the structure of the title compound, C(10)H(10)O(4), the carboxyl group forms a catemer motif in the [100] direction instead of the expected dimeric structures. The carboxylic acid group is...