Alaa Al-Hashimi
Overview
Explore the profile of Alaa Al-Hashimi including associated specialties, affiliations and a list of published articles.
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Articles
10
Citations
70
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0
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Recent Articles
1.
Venugopalan V, Rehders M, Weber J, Rodermund L, Al-Hashimi A, Bargmann T, et al.
J Mol Endocrinol
. 2022 Sep;
70(1).
PMID: 36129170
Proteolytic cleavage of thyroglobulin (Tg) for thyroid hormone (TH) liberation is followed by TH release from thyroid follicles into the circulation, enabled by TH transporters. The existence of a functional...
2.
Qatato M, Venugopalan V, Al-Hashimi A, Rehders M, Valentine A, Hein Z, et al.
Cells
. 2021 Jul;
10(6).
PMID: 34208608
Trace amine-associated receptor 1 (rodent Taar1/human TAAR1) is a G protein-coupled receptor that is mainly recognized for its functions in neuromodulation. Previous in vitro studies suggested that Taar1 may signal...
3.
Venugopalan V, Al-Hashimi A, Weber J, Rehders M, Qatato M, Wirth E, et al.
Int J Mol Sci
. 2021 Jun;
22(11).
PMID: 34071318
Cathepsin K-mediated thyroglobulin proteolysis contributes to thyroid hormone (TH) liberation, while TH transporters like Mct8 and Mct10 ensure TH release from thyroid follicles into the blood circulation. Thus, thyroid stimulating...
4.
Venugopalan V, Al-Hashimi A, Rehders M, Golchert J, Reinecke V, Homuth G, et al.
Int J Mol Sci
. 2021 Jan;
22(1).
PMID: 33466458
The thyroid gland is both a thyroid hormone (TH) generating as well as a TH responsive organ. It is hence crucial that cathepsin-mediated proteolytic cleavage of the precursor thyroglobulin is...
5.
Al-Hashimi A, Venugopalan V, Rehders M, Sereesongsaeng N, Hein Z, Springer S, et al.
Int J Mol Sci
. 2020 Dec;
21(23).
PMID: 33266306
The significance of cysteine cathepsins for the liberation of thyroid hormones from the precursor thyroglobulin was previously shown by in vivo and in vitro studies. Cathepsin L is most important...
6.
Al-Hashimi A, Venugopalan V, Sereesongsaeng N, Tedelind S, Pinzaru A, Hein Z, et al.
Biochim Biophys Acta Mol Cell Res
. 2020 Sep;
1867(12):118846.
PMID: 32910988
Altered expression and/or localization of cysteine cathepsins is believed to involve in thyroid diseases including cancer. Here, we examined the localization of cathepsins B and V in human thyroid tissue...
7.
Brix K, Szumska J, Weber J, Qatato M, Venugopalan V, Al-Hashimi A, et al.
Exp Clin Endocrinol Diabetes
. 2020 Feb;
128(6-07):437-445.
PMID: 32074633
This mini-review asks how self-regulation of the thyroid gland is realized at the cellular and molecular levels by canonical and non-canonical means. Canonical pathways of thyroid regulation comprise thyroid stimulating...
8.
Szumska J, Batool Z, Al-Hashimi A, Venugopalan V, Skripnik V, Schaschke N, et al.
Biochimie
. 2019 Jul;
166:270-285.
PMID: 31302164
Taar1 is a G protein-coupled receptor (GPCR) confined to primary cilia of rodent thyroid epithelial cells. Taar1-deficient mouse thyroid follicles feature luminal accumulation of thyroglobulin suggesting that Taar1 acts as...
9.
Rezk A, Al-Hashimi A, John W, Schepker H, Ullrich M, Brix K
BMC Complement Altern Med
. 2015 Oct;
15:364.
PMID: 26470706
Background: Rhododendron leaf extracts were previously found to exert antimicrobial activities against a range of Gram-positive bacteria. In this study, we investigated which of the extracts with these antimicrobial properties...
10.
Brix K, McInnes J, Al-Hashimi A, Rehders M, Tamhane T, Haugen M
Protoplasma
. 2014 Nov;
252(3):755-74.
PMID: 25398648
Proteases play essential roles in protein degradation, protein processing, and extracellular matrix remodeling in all cell types and tissues. They are also involved in protein turnover for maintenance of homeostasis...