Akito Natsume
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Explore the profile of Akito Natsume including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
341
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Recent Articles
1.
Nakagawa T, Natsume A, Satoh M, Niwa R
Leuk Res
. 2009 Dec;
34(5):666-71.
PMID: 20022111
We demonstrate herein the augmentation of rituximab-mediated apoptosis in lymphoma cell lines by cross-linking with recombinant FcgammaRs, which is further enhanced by using a nonfucosylated variant of rituximab having strong...
2.
Natsume A, Niwa R, Satoh M
Drug Des Devel Ther
. 2009 Nov;
3:7-16.
PMID: 19920917
As platforms for therapeutic agents, monoclonal antibodies (MAbs) have already been approved, and several MAbs have demonstrated clinical effectiveness in a variety of malignancies. However, several issues have also been...
3.
Natsume A, Shimizu-Yokoyama Y, Satoh M, Shitara K, Niwa R
Cancer Sci
. 2009 Sep;
100(12):2411-8.
PMID: 19758394
One of the major issues in current antibody therapy is insufficient efficacy. Various biological factors relating to the host's immune system or tumor cells have been suggested to reduce the...
4.
Natsume A, In M, Takamura H, Nakagawa T, Shimizu Y, Kitajima K, et al.
Cancer Res
. 2008 May;
68(10):3863-72.
PMID: 18483271
Enhancement of multiple effector functions of an antibody may be a promising approach for antibody therapy. We have previously reported that fucose removal from Fc-linked oligosaccharides greatly enhances antibody-dependent cellular...
5.
Natsume A, Wakitani M, Yamane-Ohnuki N, Shoji-Hosaka E, Niwa R, Uchida K, et al.
J Biochem
. 2006 Jul;
140(3):359-68.
PMID: 16861252
Bispecific antibodies (bsAbs) have the potential to extend binding selectivity, increase avidity and exert potent cytotoxicity due to the combination of dual specificities. scFv2-Fc type of single-gene-encoded bispecific antibody, composed...
6.
Natsume A, Wakitani M, Yamane-Ohnuki N, Shoji-Hosaka E, Niwa R, Uchida K, et al.
J Immunol Methods
. 2005 Oct;
306(1-2):93-103.
PMID: 16236307
Fucose removal from complex-type oligosaccharide of human IgG1-type antibody results in a great enhancement of antibody-dependent cellular cytotoxicity (ADCC). The aim of this study was to clarify the effect of...
7.
Niwa R, Natsume A, Uehara A, Wakitani M, Iida S, Uchida K, et al.
J Immunol Methods
. 2005 Oct;
306(1-2):151-60.
PMID: 16219319
Fucose depletion from oligosaccharides of human IgG1-type antibodies results in a great enhancement of antibody-dependent cellular cytotoxicity (ADCC). The aim of this study was to clarify the effect of fucose...