Akinori Matsushita
Overview
Explore the profile of Akinori Matsushita including associated specialties, affiliations and a list of published articles.
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10
Citations
73
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0
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Recent Articles
1.
Uno Y, Matsushita A, Murayama N, Yamazaki H
Drug Metab Pharmacokinet
. 2017 May;
32(3):192.
PMID: 28522025
No abstract available.
2.
Koyama S, Fukuda K, Watanabe S, Matsushita A, Tsuchiya H, Fujinami N, et al.
Drug Metab Pharmacokinet
. 2017 Feb;
32(1):112-115.
PMID: 28153493
Cynomolgus macaques are an important primate species for drug metabolism studies; however cynomolgus CYP2C76, an important drug-metabolizing enzyme, accounts for drug metabolism differences to humans, so that CYP2C76-null animals might...
3.
Uno Y, Matsushita A, Murayama N, Yamazaki H
Drug Metab Pharmacokinet
. 2015 Mar;
30(1):130-2.
PMID: 25760542
Cynomolgus and rhesus macaques are non-human primate species widely used in drug metabolism studies. Cynomolgus CYP2C9 (formerly known as CYP2C43) is predominantly expressed in liver and encodes a drug-metabolizing enzyme...
4.
Uno Y, Matsushita A, Shukuya M, Matsumoto Y, Murayama N, Yamazaki H
Biochem Pharmacol
. 2014 Jul;
91(2):242-8.
PMID: 25036290
CYP2C19 (formerly known as CYP2C75), highly homologous to human CYP2C19, has been identified in cynomolgus and rhesus macaques, non-human primate species widely used in drug metabolism studies. CYP2C19 is predominantly...
5.
Uno Y, Matsushita A, Yamazaki H
J Vet Med Sci
. 2011 May;
73(9):1229-31.
PMID: 21551978
Cytochrome P450 (CYP) 1B1 is involved in the metabolic activation of various procarcinogens, and some CYP1B1 genetic variants alter CYP1B1-dependent procarcinogen metabolism. Cynomolgus and rhesus macaques are frequently used in...
6.
Nakanishi Y, Matsushita A, Matsuno K, Iwasaki K, Utoh M, Nakamura C, et al.
Drug Metab Pharmacokinet
. 2011 Jan;
26(3):288-94.
PMID: 21273732
The cynomolgus monkey is an animal species widely used to study drug metabolism because of its evolutionary closeness to humans. However, drug-metabolizing enzyme activities have not been compared in various...
7.
Amano T, Tokunaga K, Kakegawa R, Yanagisawa A, Takemoto A, Tatemizo A, et al.
Anim Reprod Sci
. 2010 Jul;
121(3-4):225-35.
PMID: 20619978
We previously showed that circadian genes clock, bmal1, cry1, cry2, per1, and per2 are expressed and function as maternal mRNA regulating events in the oocytes and preimplantation embryos of mice....
8.
Nakanishi Y, Matsushita A, Matsuno K, Iwasaki K, Utoh M, Nakamura C, et al.
Drug Metab Pharmacokinet
. 2010 Jul;
25(3):290-7.
PMID: 20610888
The cynomolgus monkey is used to study drug metabolism because of its evolutionary closeness to humans. Despite their importance, regional distribution of cytochrome P450 (CYP) enzymes including CYP3As in the...
9.
Uno Y, Matsushita A, Osada N, Uehara S, Kohara S, Nagata R, et al.
Drug Metab Dispos
. 2009 Nov;
38(2):209-14.
PMID: 19910514
Cynomolgus and rhesus macaques are frequently used in preclinical trials due to their close evolutionary relationships to humans. We conducted an initial screening for genetic variants in cynomolgus and rhesus...
10.
Amano T, Matsushita A, Hatanaka Y, Watanabe T, Oishi K, Ishida N, et al.
Biol Reprod
. 2008 Nov;
80(3):473-83.
PMID: 19020302
In mammals, circadian genes, Clock, Arntl (also known as Bmal1), Cry1, Cry2, Per1, Per2, and Per3, are rhythmically transcribed every 24 h in almost all organs and tissues to tick...