Aki Koike
Overview
Explore the profile of Aki Koike including associated specialties, affiliations and a list of published articles.
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Articles
35
Citations
231
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0
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Recent Articles
1.
Koike M, Yamashita H, Yutoku Y, Koike A
Sci Rep
. 2024 Jan;
14(1):1188.
PMID: 38216643
Ku70 is a multifunctional protein with pivotal roles in DNA repair via non-homologous end-joining, V(D)J recombination, telomere maintenance, and neuronal apoptosis control. Nonetheless, its regulatory mechanisms remain elusive. Chicken Ku70...
2.
Fujimoto H, Ikuta T, Koike A, Koike M
Biochem Biophys Rep
. 2023 Jan;
33:101418.
PMID: 36620088
Proteins are functionally regulated by various types of posttranslational modifications (PTMs). Ku, a heterodimer complex of Ku70 and Ku80 subunits, participates in DNA repair processes. Ku is distributed not only...
3.
Koike M, Yutoku Y, Koike A
J Vet Med Sci
. 2022 Sep;
84(11):1485-1490.
PMID: 36104184
Uncovering radiation toxicity is critical for the adaptation and expansion of advanced radiation therapies and for the development of novel cancer radiotherapy. In the near future, advanced radiotherapies, including heavy...
4.
Koike M, Yutoku Y, Koike A
FEBS Open Bio
. 2022 Jan;
12(4):798-810.
PMID: 35000298
Radiation and chemotherapy resistance remain some of the greatest challenges in human and veterinary cancer therapies. XRCC4, an essential molecule for nonhomologous end joining repair, is a promising target for...
5.
Ikuta T, Koike A, Koike M
J Toxicol Sci
. 2021 Dec;
46(12):611-618.
PMID: 34853246
The gastrointestinal tract is exposed to a myriad of mutagens, making the DNA damage response (DDR) essential to maintain intestinal homeostasis. In vivo models to study DDRs are necessary to...
6.
Koike M, Yutoku Y, Koike A
J Vet Med Sci
. 2021 Mar;
83(5):798-804.
PMID: 33731502
Radioresistance and radiotoxicity have been reported following cancer treatments in felines. Optimizing radiation doses to induce cytotoxic effects to only cancer cells and not normal cells is critical in achieving...
7.
Kinoshita K, Suzuki T, Koike M, Nishida C, Koike A, Nunome M, et al.
Commun Biol
. 2020 Mar;
3(1):144.
PMID: 32214226
The Creeper (Cp) chicken is characterized by chondrodystrophy in Cp/+ heterozygotes and embryonic lethality in Cp/Cp homozygotes. However, the genes underlying the phenotypes have not been fully known. Here, we...
8.
Koike M, Yutoku Y, Koike A
FEBS Open Bio
. 2019 May;
9(6):1052-1062.
PMID: 31115163
Resistance to radiotherapy and chemotherapy is a common problem in the treatment of cancer in humans and companion animals, including cats. There is thus an urgent need to develop new...
9.
Koike M, Yutoku Y, Koike A
FEBS Open Bio
. 2017 Dec;
7(12):1854-1863.
PMID: 29226073
Molecularly targeted therapies have high specificity and significant cancer-killing effect. However, their antitumor effect might be greatly diminished by variation in even a single amino acid in the target site,...
10.
Koike M, Yutoku Y, Koike A
J Vet Med Sci
. 2017 Feb;
79(3):554-561.
PMID: 28163277
Understanding the molecular mechanisms of DNA double-strand break (DSB) repair machinery, specifically non-homologous DNA-end joining (NHEJ), is crucial for developing next-generation radiotherapies and common chemotherapeutics for human and animal cancers....