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» Authors » Akhil Shukla

Akhil Shukla

Explore the profile of Akhil Shukla including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 8
Citations 41
Followers 0
Related Specialties
Biochemistry
Molecular Biology
Cardiology & Vascular Diseases
Top 10 Co-Authors
Sheela Ramanathan
Subburaj Ilangumaran
Madanraj Appiya Santharam
Francois-Michel Boisvert
Maryse Cloutier
Dominique Levesque
Thomas A Kufer
Akouavi Julite I Quenum
Nicholas Bett
Yirui Gui
Published In
Int J Mol Sci
Front Immunol
Circ Cardiovasc Imaging
CASE (Phila)
Biochimie
Affiliations
Soon will be listed here.
Recent Articles
1.
SOCS1 expression in cancer cells: potential roles in promoting antitumor immunity
Ilangumaran S, Gui Y, Shukla A, Ramanathan S
Front Immunol . 2024 Feb; 15:1362224. PMID: 38415248
Suppressor of cytokine signaling 1 (SOCS1) is a potent regulator immune cell responses and a proven tumor suppressor. Inhibition of SOCS1 in T cells can boost antitumor immunity, whereas its...
2.
The Tumor Suppressor SOCS1 Diminishes Tolerance to Oxidative Stress in Hepatocellular Carcinoma
Shukla A, Khan M, Cayarga A, Namvarpour M, Chowdhury M, Levesque D, et al.
Cancers (Basel) . 2024 Jan; 16(2). PMID: 38254783
SOCS1 is a tumor suppressor in hepatocellular carcinoma (HCC). Recently, we showed that a loss of SOCS1 in hepatocytes promotes NRF2 activation. Here, we investigated how SOCS1 expression in HCC...
3.
NLRC5-CIITA Fusion Protein as an Effective Inducer of MHC-I Expression and Antitumor Immunity
Santharam M, Shukla A, Levesque D, Kufer T, Boisvert F, Ramanathan S, et al.
Int J Mol Sci . 2023 Apr; 24(8). PMID: 37108368
Aggressive tumors evade cytotoxic T lymphocytes by suppressing MHC class-I (MHC-I) expression that also compromises tumor responsiveness to immunotherapy. MHC-I defects strongly correlate to defective expression of NLRC5, the transcriptional...
4.
NLRC5 Deficiency Deregulates Hepatic Inflammatory Response but Does Not Aggravate Carbon Tetrachloride-Induced Liver Fibrosis
Quenum A, Shukla A, Rexhepi F, Cloutier M, Ghosh A, Kufer T, et al.
Front Immunol . 2021 Oct; 12:749646. PMID: 34712238
The nucleotide-binding leucine-rich repeat-containing receptor (NLR) family protein-5 (NLRC5) controls NF-κB activation and production of inflammatory cytokines in certain cell types. NLRC5 is considered a potential regulator of hepatic fibrogenic...
5.
The MHC Class-I Transactivator NLRC5: Implications to Cancer Immunology and Potential Applications to Cancer Immunotherapy
Shukla A, Cloutier M, Santharam M, Ramanathan S, Ilangumaran S
Int J Mol Sci . 2021 Mar; 22(4). PMID: 33671123
The immune system constantly monitors the emergence of cancerous cells and eliminates them. CD8 cytotoxic T lymphocytes (CTLs), which kill tumor cells and provide antitumor immunity, select their targets by...
6.
SILAC proteomics implicates SOCS1 in modulating cellular macromolecular complexes and the ubiquitin conjugating enzyme UBE2D involved in MET receptor tyrosine kinase downregulation
Santharam M, Shukla A, Ihsan A, Cloutier M, Levesque D, Ramanathan S, et al.
Biochimie . 2021 Jan; 182:185-196. PMID: 33493533
Suppressor of Cytokine Signaling 1 (SOCS1) functions as a tumor suppressor in hepatocellular carcinoma and many other types of cancers. SOCS1 mediates its functions by inhibiting tyrosine kinases, promoting ubiquitination...
7.
Transthyretin Cardiac Amyloidosis: A Noninvasive Multimodality Approach to Diagnosis Using Transthoracic Echocardiography, 99m-Tc-Labeled Phosphate Bone Scanning, and Cardiac Magnetic Resonance Imaging
Shukla A, Wong D, Humphries J, Fitzgerald B, Newbigin K, Bashford J, et al.
CASE (Phila) . 2018 Aug; 1(2):49-53. PMID: 30062242
No abstract available.
8.
Massive left atrial thrombus in a patient with rheumatic mitral stenosis and atrial fibrillation while anticoagulated with dabigatran
Luis S, Poon K, Luis C, Shukla A, Bett N, Hamilton-Craig C
Circ Cardiovasc Imaging . 2013 May; 6(3):491-2. PMID: 23696587
No abstract available.